Plants are fascinating and complex organisms. A comprehensive understanding of the
organization, function and evolution of plant genes is essential to disentangle important …

Genes that are thought to be critical for the survival of organisms or cells are called essential
genes. The prediction of essential genes and their products (essential proteins) is of great …

Background and scope Nowadays, centrality analysis has become a principal method for
identifying essential proteins in biological networks. Here we present CytoNCA, a Cytoscape …

Proteins differentially interact with each other across cellular states and conditions, but an
efficient proteome-wide strategy to monitor them is lacking. We report the application of …

Motivation: Protein complexes are important for understanding principles of cellular
organization and function. High-throughput experimental techniques have produced a large …

Genome-wide association studies (GWAS) have identified loci linked to hundreds of traits in
many different species. Yet, because linkage equilibrium implicates a broad region …

Cluster analysis of biological networks is one of the most important approaches for
identifying functional modules and predicting protein functions. Furthermore, visualization of …

As advances in the technologies of predicting protein interactions, huge data sets portrayed
as networks have been available. Identification of functional modules from such networks is …

Cellular processes are typically carried out by protein complexes and functional modules.
Identifying them plays an important role for our attempt to reveal principles of cellular …

Protein complexes are crucial in improving our understanding of the mechanisms employed
by proteins. Various computational algorithms have thus been proposed to detect protein …