The advent of the patch-clamp technique has revolutionized the study of membrane
physiology [1, 2]. The last decade has witnessed its wide application to virtually every …

The psychoactive properties of Cannabis sativa and its major biologically active constituent,
delta 9-tetrahydrocannabinol, have been known for years. The recent identification and …

We present experimental procedures describing the creation of perforated patches by use of
amphotericin B. In 13 different cellular preparations, access resistances below 10 MΩ were …

ALTHOUGH many glial cells possess neurotransmitter receptors and transporters1–5, little
is known about glial participation in neurotransmission. To explore this issue, we recorded …

Shear stress–induced activation of endothelial ion channels, one of the earliest responses to
flow, is implicated in mechano–signal transduction that results in the regulation of vascular …

Obesity is an epidemic, calling for innovative and reliable pharmacological strategies. Here,
we show that ShK-186, a selective and potent blocker of the voltage-gated Kv1. 3 channel …

Mutations in α‐synuclein cause some cases of familial Parkinson's disease (PD), but the
mechanism by which α‐synuclein promotes degeneration of dopamine‐producing neurons …

1. Paired‐pulse modulation of excitatory non‐N‐methyl‐D‐aspartate (non‐NMDA) receptor‐
mediated autaptic currents and conventional monosynaptic (interneuronal) excitatory …

The aim of the study was to examine the effects of α2-adrenoreceptor agonists on the
excitability of trigeminal root ganglion (TRG) neurons using the perforated patch-clamp …

We find that the adrenergic agonist isoproterenol increases intracellular Ca2+ concentration
([Ca2+] i) in cultured rat brown adipocytes. At the concentration used (10 μM), isoproterenol …