To date, almost 2600 gene therapy clinical trials have been completed, are ongoing or have
been approved worldwide. Our database brings together global information on gene therapy …

Conventional methods of DNA sequence insertion into plants, using Agrobacterium-
mediated transformation or microprojectile bombardment, result in the integration of the DNA …

Haematopoietic stem cell (HSC) gene therapy has been successfully employed as a
therapeutic option to treat specific inherited immune deficiencies, including severe …

Gene editing, which allows for specific location (s) in the genome to be targeted and altered
by deleting, adding or substituting nucleotides, is currently the subject of important academic …

Gene editing is arguably the most significant recent addition to the modern biotechnology
toolbox, bringing both profoundly challenging and enabling opportunities. From a technical …

Genome editing tools have already revolutionized biomedical research and are also
expected to have an important impact in the clinic. However, their extensive use in research …

Widespread utilization of small GTPases as major regulatory hubs in many different
biological systems derives from a conserved conformational switch mechanism that …

The goal of personalised medicine is to develop tailor-made therapies for patients in whom
currently available therapeutics fail. This approach requires correlating individual patient …

Plants are able to recognize conserved features of potential microbial invaders and mount
an active defense in most cases. Over the course of evolution, a number of these microbes …

Cortical development depends on neuronal migration of both excitatory and inhibitory
interneurons. Neuronal migration disorders (NMDs) are conditions characterised by …