Mechanics of diseased red blood cells in human spleen and consequences for hereditary blood disorders
In red blood cell (RBC) diseases, the spleen contributes to anemia by clearing the damaged
RBCs, but its unique ability to mechanically challenge RBCs also poses the risk of inducing …
RBCs, but its unique ability to mechanically challenge RBCs also poses the risk of inducing …
Biomechanics of phagocytosis of red blood cells by macrophages in the human spleen
The clearance of senescent and altered red blood cells (RBCs) in the red pulp of the human
spleen involves sequential processes of prefiltration, filtration, and postfiltration. While prior …
spleen involves sequential processes of prefiltration, filtration, and postfiltration. While prior …
How the spleen reshapes and retains young and old red blood cells: A computational investigation
The spleen, the largest secondary lymphoid organ in humans, not only fulfils a broad range
of immune functions, but also plays an important role in red blood cell's (RBC) life cycle …
of immune functions, but also plays an important role in red blood cell's (RBC) life cycle …
On the effects of membrane viscosity on transient red blood cell dynamics
Computational Fluid Dynamics (CFD) is currently used to design and improve the hydraulic
properties of biomedical devices, wherein the large scale blood circulation needs to be …
properties of biomedical devices, wherein the large scale blood circulation needs to be …
Multiphysics and multiscale modeling of microthrombosis in COVID-19
Emerging clinical evidence suggests that thrombosis in the microvasculature of patients with
Coronavirus disease 2019 (COVID-19) plays an essential role in dictating the disease …
Coronavirus disease 2019 (COVID-19) plays an essential role in dictating the disease …
Synergistic integration of laboratory and numerical approaches in studies of the biomechanics of diseased red blood cells
In red blood cell (RBC) disorders, such as sickle cell disease, hereditary spherocytosis, and
diabetes, alterations to the size and shape of RBCs due to either mutations of RBC proteins …
diabetes, alterations to the size and shape of RBCs due to either mutations of RBC proteins …
In silico and in vitro study of the adhesion dynamics of erythrophagocytosis in sickle cell disease
Erythrophagocytosis occurring in the spleen is a critical process for removing senescent and
diseased red blood cells (RBCs) from the microcirculation. Although some progress has …
diseased red blood cells (RBCs) from the microcirculation. Although some progress has …
Quantitative prediction of flow dynamics and mechanical retention of surface-altered red blood cells through a splenic slit
Normal red blood cells (RBCs) have remarkable properties of deformability, which enable
them to squeeze through tiny splenic inter-endothelial slits (IESs) without any damage …
them to squeeze through tiny splenic inter-endothelial slits (IESs) without any damage …
Multiscale computational framework for predicting viscoelasticity of red blood cells in aging and mechanical fatigue
Red blood cells (RBCs) experience significant cyclic deformation through large elastic
stretching and relaxation as they circulate in the bloodstream. Such hundreds of thousands …
stretching and relaxation as they circulate in the bloodstream. Such hundreds of thousands …
Modeling of biomechanics and biorheology of red blood cells in type 2 diabetes mellitus
Erythrocytes in patients with type-2 diabetes mellitus (T2DM) are associated with reduced
cell deformability and elevated blood viscosity, which contribute to impaired blood flow and …
cell deformability and elevated blood viscosity, which contribute to impaired blood flow and …