The therapeutic potential of psilocybin

H Lowe, N Toyang, B Steele, H Valentine, J Grant, A Ali… - Molecules, 2021 - mdpi.com
The psychedelic effects of some plants and fungi have been known and deliberately
exploited by humans for thousands of years. Fungi, particularly mushrooms, are the principal …

Default mode network modulation by psychedelics: a systematic review

JJ Gattuso, D Perkins, S Ruffell… - International Journal …, 2023 - academic.oup.com
Psychedelics are a unique class of drug that commonly produce vivid hallucinations as well
as profound psychological and mystical experiences. A grouping of interconnected brain …

Models of psychedelic drug action: modulation of cortical-subcortical circuits

MK Doss, MB Madden, A Gaddis, MB Nebel… - Brain, 2022 - academic.oup.com
Classic psychedelic drugs such as psilocybin and lysergic acid diethylamide (LSD) have
recaptured the imagination of both science and popular culture, and may have efficacy in …

A triple-network organization for the mouse brain

F Mandino, RM Vrooman, HE Foo, LY Yeow… - Molecular …, 2022 - nature.com
The triple-network model of psychopathology is a framework to explain the functional and
structural neuroimaging phenotypes of psychiatric and neurological disorders. It describes …

Psilocybin efficacy and mechanisms of action in major depressive disorder: a review

D Prouzeau, I Conejero, PL Voyvodic… - Current Psychiatry …, 2022 - Springer
Abstract Purpose of the Review We aim to provide an overview of the current state of
knowledge about the efficacy of psilocybin in the treatment of depression, as well as its …

Psychedelic therapy's transdiagnostic effects: a research domain criteria (RDoC) perspective

JR Kelly, CM Gillan, J Prenderville, C Kelly… - Frontiers in …, 2021 - frontiersin.org
Accumulating clinical evidence shows that psychedelic therapy, by synergistically combining
psychopharmacology and psychological support, offers a promising transdiagnostic …

Modeling brain dysconnectivity in rodents

A Gozzi, V Zerbi - Biological Psychiatry, 2023 - Elsevier
Altered or atypical functional connectivity as measured with functional magnetic resonance
imaging (fMRI) is a hallmark feature of brain connectopathy in psychiatric, developmental …

The zebrafish for preclinical psilocybin research

O Syed, B Tsang, R Gerlai - Neuroscience & Biobehavioral Reviews, 2023 - Elsevier
In this review, we discuss the possible utility of zebrafish in research on psilocybin, a
psychedelic drug whose recreational use as well as possible clinical application are gaining …

Psilocybin restrains activity-based anorexia in female rats by enhancing cognitive flexibility: contributions from 5-HT1A and 5-HT2A receptor mechanisms

K Conn, LK Milton, K Huang, H Munguba… - Molecular …, 2024 - nature.com
Psilocybin has shown promise for alleviating symptoms of depression and is currently in
clinical trials for the treatment of anorexia nervosa (AN), a condition that is characterised by …

Probing the antidepressant potential of psilocybin: integrating insight from human research and animal models towards an understanding of neural circuit mechanisms

J Meccia, J Lopez, RC Bagot - Psychopharmacology, 2023 - Springer
Interest in the therapeutic potential of serotonergic psychedelic compounds including
psilocybin has surged in recent years. While human clinical research suggests psilocybin …