Rapamycin, a macrocyclic lactone, is a highly specific inhibitor of the serine/threonine
protein kinase target of rapamycin (TOR). Although it is clear that TOR controls initiation of …

Regulation of protein synthesis in eukaryotes plays a critical role in development,
differentiation, cell cycle progression, cell growth, and apoptosis (Mathews et al. 2000) …

The mTOR kinase controls cell growth, proliferation, and survival through two distinct
multiprotein complexes, mTORC1 and mTORC2. mTOR and mLST8 are in both complexes …

TOR is a serine-threonine kinase that was originally identified as a target of rapamycin in
Saccharomyces cerevisiae and then found to be highly conserved among eukaryotes. In …

Rapamycin potently inhibits downstream signaling from the target of rapamycin (TOR)
proteins. These evolutionarily conserved protein kinases coordinate the balance between …

Mammalian target of rapamycin (mTOR) is a conserved serine/threonine kinase of the
phosphatidylinositol kinase-related kinase family that regulates cell growth, metabolism, and …

The mammalian target of rapamycin, mTOR, is a protein Ser-Thr kinase that functions as a
central element in a signaling pathway involved in the control of cell growth and …

Target of rapamycin (TOR) proteins are members of the phosphatidylinositol kinase-related
kinase (PIKK) family and are highly conserved from yeast to mammals. TOR proteins …

Mouse embryos bearing hypomorphic and conditional null Fgf8 mutations have small and
abnormally patterned telencephalons. We provide evidence that the hypoplasia results from …

Developing animals survive periods of starvation by protecting the growth of critical organs
at the expense of other tissues. Here, we use Drosophila to explore the as yet unknown …