High-throughput RNA sequencing (RNA-seq) promises a comprehensive picture of the transcriptome, allowing for the complete annotation and quantification of all genes and their …
How can the genome of Drosophila melanogaster contain fewer genes than the undoubtedly simpler organism Caenorhabditis elegans? The answer must lie within their …
Assembling a comprehensive catalog of common human sequence polymorphisms is a key goal of the Human Genome Project. The International SNP Map Working Group has …
The origin story and emergence of molecular biology is muddled. The early triumphs in bacterial genetics and the complexity of animal and plant genomes complicate an intricate …
S Saha, AB Sparks, C Rago, V Akmaev, CJ Wang… - Nature …, 2002 - nature.com
A remaining challenge for the human genome project involves the identification and annotation of expressed genes. The public and private sequencing efforts have identified∼ …
DD Shoemaker, EE Schadt, CD Armour, YD He… - Nature, 2001 - nature.com
The most important product of the sequencing of a genome is a complete, accurate catalogue of genes and their products, primarily messenger RNA transcripts and their …
JL Rinn, G Euskirchen, P Bertone… - Genes & …, 2003 - genesdev.cshlp.org
A DNA microarray representing nearly all of the unique sequences of human Chromosome 22 was constructed and used to measure global-transcriptional activity in placental poly (A)+ …
A crucial aim upon the completion of the human genome is the verification and functional annotation of all predicted genes and their protein products. Here we describe the mapping …
An international consortium is the driving force behind several new genome-related projects, mainly focused on Eimeria tenella, the cause of avian, caecal coccidiosis. The largest …