Roles of chromatin and genome instability in cellular senescence and their relevance to ageing and related diseases
Ageing is a complex biological process in which a gradual decline in physiological fitness
increases susceptibility to diseases such as neurodegenerative disorders and cancer …
increases susceptibility to diseases such as neurodegenerative disorders and cancer …
Decoding aging hallmarks at the single-cell level
S Ma, X Chi, Y Cai, Z Ji, S Wang, J Ren… - Annual Review of …, 2023 - annualreviews.org
Organismal aging exhibits wide-ranging hallmarks in divergent cell types across tissues,
organs, and systems. The advancement of single-cell technologies and generation of rich …
organs, and systems. The advancement of single-cell technologies and generation of rich …
m6A epitranscriptomic regulation of tissue homeostasis during primate aging
Abstract How N 6-methyladenosine (m6A), the most abundant mRNA modification,
contributes to primate tissue homeostasis and physiological aging remains elusive. Here …
contributes to primate tissue homeostasis and physiological aging remains elusive. Here …
Nuclear lamina erosion-induced resurrection of endogenous retroviruses underlies neuronal aging
The primate frontal lobe (FL) is sensitive to aging-related neurocognitive decline. However,
the aging-associated molecular mechanisms remain unclear. Here, using physiologically …
the aging-associated molecular mechanisms remain unclear. Here, using physiologically …
A single-cell transcriptomic atlas of exercise-induced anti-inflammatory and geroprotective effects across the body
Exercise benefits the whole organism, yet, how tissues across the body orchestrally respond
to exercise remains enigmatic. Here, in young and old mice, with or without exercise, and …
to exercise remains enigmatic. Here, in young and old mice, with or without exercise, and …
Exploring the heterogeneous targets of metabolic aging at single-cell resolution
Our limited understanding of metabolic aging poses major challenges to comprehending the
diverse cellular alterations that contribute to age-related decline, and to devising targeted …
diverse cellular alterations that contribute to age-related decline, and to devising targeted …
[HTML][HTML] Aging hallmarks of the primate ovary revealed by spatiotemporal transcriptomics
The ovary is indispensable for female reproduction, and its age-dependent functional
decline is the primary cause of infertility. However, the molecular basis of ovarian aging in …
decline is the primary cause of infertility. However, the molecular basis of ovarian aging in …
A nutrigeroscience approach: Dietary macronutrients and cellular senescence
MF Calubag, PD Robbins, DW Lamming - Cell Metabolism, 2024 - cell.com
Cellular senescence, a process in which a cell exits the cell cycle in response to stressors, is
one of the hallmarks of aging. Senescence and the senescence-associated secretory …
one of the hallmarks of aging. Senescence and the senescence-associated secretory …
Reducing oxidative protein folding alleviates senescence by minimizing ER‐to‐nucleus H2O2 release
Oxidative protein folding occurs in the endoplasmic reticulum (ER) to generate disulfide
bonds, and the by‐product is hydrogen peroxide (H2O2). However, the relationship between …
bonds, and the by‐product is hydrogen peroxide (H2O2). However, the relationship between …
Biomarkers of aging
Aging Biomarker Consortium, H Bao, J Cao… - Science China Life …, 2023 - Springer
Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …