Advances in oligonucleotide drug delivery
TC Roberts, R Langer, MJA Wood - Nature reviews Drug discovery, 2020 - nature.com
Oligonucleotides can be used to modulate gene expression via a range of processes
including RNAi, target degradation by RNase H-mediated cleavage, splicing modulation …
including RNAi, target degradation by RNase H-mediated cleavage, splicing modulation …
Mechanisms, applications, and challenges of insect RNA interference
The RNA interference (RNAi) triggered by short/small interfering RNA (siRNA) was
discovered in nematodes and found to function in most living organisms. RNAi has been …
discovered in nematodes and found to function in most living organisms. RNAi has been …
Molecular map of chronic lymphocytic leukemia and its impact on outcome
Recent advances in cancer characterization have consistently revealed marked
heterogeneity, impeding the completion of integrated molecular and clinical maps for each …
heterogeneity, impeding the completion of integrated molecular and clinical maps for each …
Structure of the human DICER–pre-miRNA complex in a dicing state
Dicer has a key role in small RNA biogenesis, processing double-stranded RNAs
(dsRNAs),. Human DICER (hDICER, also known as DICER1) is specialized for cleaving …
(dsRNAs),. Human DICER (hDICER, also known as DICER1) is specialized for cleaving …
Structural and functional basis of mammalian microRNA biogenesis by Dicer
D Zapletal, E Taborska, J Pasulka, R Malik, K Kubicek… - Molecular cell, 2022 - cell.com
MicroRNA (miRNA) and RNA interference (RNAi) pathways rely on small RNAs produced by
Dicer endonucleases. Mammalian Dicer primarily supports the essential gene-regulating …
Dicer endonucleases. Mammalian Dicer primarily supports the essential gene-regulating …
Diversifying microRNA sequence and function
MicroRNAs (miRNAs) regulate the expression of most genes in animals, but we are only
now beginning to understand how they are generated, assembled into functional complexes …
now beginning to understand how they are generated, assembled into functional complexes …
5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease
Lipoxygenase (5-LOX) catalyzes two steps in the biosynthesis of leukotrienes (LTs), lipid
mediators of inflammation derived from arachidonic acid. In this review we focus on 5-LOX …
mediators of inflammation derived from arachidonic acid. In this review we focus on 5-LOX …
MicroRNA: biogenesis, function and role in cancer
LA MacFarlane, PR Murphy - Current genomics, 2010 - ingentaconnect.com
MicroRNAs are small, highly conserved non-coding RNA molecules involved in the
regulation of gene expression. MicroRNAs are transcribed by RNA polymerases II and III …
regulation of gene expression. MicroRNAs are transcribed by RNA polymerases II and III …
Phase separation of SERRATE drives dicing body assembly and promotes miRNA processing in Arabidopsis
MicroRNA (miRNA) production entails the step-wise processing of primary miRNAs (pri-
miRNAs) into precursor miRNAs (pre-miRNAs) and miRNA/* duplexes by Dicing complexes …
miRNAs) into precursor miRNAs (pre-miRNAs) and miRNA/* duplexes by Dicing complexes …
RISC assembly: Coordination between small RNAs and Argonaute proteins
H Kobayashi, Y Tomari - Biochimica et Biophysica Acta (BBA)-Gene …, 2016 - Elsevier
Non-coding RNAs generally form ribonucleoprotein (RNP) complexes with their partner
proteins to exert their functions. Small RNAs, including microRNAs, small interfering RNAs …
proteins to exert their functions. Small RNAs, including microRNAs, small interfering RNAs …