Candidate pathways for retina to scleral signaling in refractive eye growth

DM Brown, R Mazade, D Clarkson-Townsend… - Experimental eye …, 2022 - Elsevier
The global prevalence of myopia, or nearsightedness, has increased at an alarming rate
over the last few decades. An eye is myopic if incoming light focuses prior to reaching the …

[HTML][HTML] IMI—the dynamic choroid: new insights, challenges, and potential significance for human myopia

LA Ostrin, E Harb, DL Nickla, SA Read… - … & visual science, 2023 - jov.arvojournals.org
The choroid is the richly vascular layer of the eye located between the sclera and Bruch's
membrane. Early studies in animals, as well as more recent studies in humans, have …

IMI 2023 digest

P Sankaridurg, DA Berntsen… - … & Visual Science, 2023 - iovs.arvojournals.org
Myopia is a dynamic and rapidly moving field, with ongoing research providing a better
understanding of the etiology leading to novel myopia control strategies. In 2019, the …

[HTML][HTML] Acute effects of oral caffeine intake on human global-flash mfERG responses: a placebo-controlled, double-masked, balanced crossover study

J Vera, B Redondo, FA Vera-Diaz… - … & Visual Science, 2024 - jov.arvojournals.org
Purpose: To determine the acute effect of caffeine intake on the retinal responses as
measured with a global-flash multifocal electroretinogram (gfmERG) protocol at different …

Oral administration of caffeine metabolite 7-methylxanthine is associated with slowed myopia progression in Danish children

K Trier, D Cui, S Ribel-Madsen… - British Journal of …, 2023 - bjo.bmj.com
Purpose Myopia is associated with an increased risk of permanent vision loss. The caffeine
metabolite 7-methylxanthine (7-MX), licensed in Denmark since 2009 as a treatment to …

[HTML][HTML] Role of 7-methylxanthine in myopia prevention and control: a mini-review

L Lai, K Trier, DM Cui - International Journal of Ophthalmology, 2023 - ncbi.nlm.nih.gov
Myopia is becoming increasingly common. By 2050 around 10% of the world's population is
expected to be highly myopic (<-5 diopters) and therefore particularly at risk of suffering from …

Retinal glia in myopia: current understanding and future directions

P Chen, J Ji, X Chen, J Zhang, X Wen… - Frontiers in Cell and …, 2024 - frontiersin.org
Myopia, a major public health problem, involves axial elongation and thinning of all layers of
the eye, including sclera, choroid and retina, which defocuses incoming light and thereby …

[HTML][HTML] Caffeine and Vision: Effects on the Eye

A Yan, A La Rosa, PP Chhablani… - Turkish Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
Caffeine, commonly found in coffee and tea, affects various aspects of eye health as it blocks
adenosine receptors, impacting tear production, intraocular pressure, macular perfusion …

[HTML][HTML] Role of caffeine in slowing progression of myopia: 1-year results from a prospective, longitudinal clinical trial

HDM Tran, YH Tran, TTX Ha, TD Tran, M Jong… - Asia-Pacific Journal of …, 2025 - Elsevier
Purpose To determine the role of topical caffeine in slowing progression of myopia, both as
a standalone treatment and in combination with atropine. Methods In a prospective …

Diurnal variation and effects of dilation and sedation on intraocular pressure in infant Rhesus monkeys

KM Beach, LF Hung, L Lou, LA Ostrin - Current eye research, 2023 - Taylor & Francis
Purpose Intraocular pressure (IOP) is an important factor in numerous ocular conditions and
research areas, including eye growth and myopia. In infant monkeys, IOP is typically …