Introduction The trigeminal ganglion is unique among the somatosensory ganglia regarding
its topography, structure, composition and possibly some functional properties of its cellular …

The trigeminal ganglion with its three trigeminal nerve tracts consists mainly of clusters of
sensory neurons with their peripheral and central processes. Most neurons are surrounded …

Aspartame is the methyl-ester of the aspartate-phenylalanine dipeptide. Over time, it has
become a very popular artificial sweetener. However, since its approval by the main food …

Capsaicin is the pungent ingredient of chili peppers and is approved as a topical treatment
of neuropathic pain. The analgesia lasts for several months after a single treatment …

Peripheral and central sensitizations of the trigeminal nervous system are the main
mechanisms to promote the development and maintenance of chronic orofacial pain …

Ethnopharmacological relevance In silico data revealed that the active compound of ginger
(Zingiber officinale Roscoe), 6-shogaol, has strong affinity toward transient receptor potential …

Migraine is a chronic neurological disorder that affects approximately 12% of the population.
The cause of migraine headaches is not yet known, however, when the trigeminal system is …

Ketamine is a racemic mixture of equal amounts of R-ketamine and S-ketamine and is well
known to anesthesiologists for its unique dissociative anesthetic properties. The …

The molecular/genetic era has seen the discovery of a staggering number of molecules
implicated in pain mechanisms [18],[35],[61],[69],[96],[133],[150],[202],[224]. This has …

Many diseases, including cancer, can lead to neuropathic pain (NP). NP is one of the
accompanying symptoms of suffering in many conditions and the life quality of NP patient is …