Skeletal muscle represents around 40% of whole body mass. The principal function of
skeletal muscle is the conversion of chemical energy toward mechanic energy to ensure the …

O-GlcNAcylation is a highly dynamic, reversible and atypical glycosylation that regulates the
activity, biological function, stability, sublocation and interaction of target proteins. O …

Abstract Background Tyrosine kinase inhibitors (TKIs) are effective therapies with
demonstrated antineoplastic activity. Nilotinib is a second-generation FDA-approved TKI …

Drug screening systems for muscle atrophy based on the contractile force of cultured
skeletal muscle tissues are required for the development of preventive or therapeutic drugs …

Atopic dermatitis (AD) is a chronic inflammatory skin disease that is associated with
intestinal microflora. Since specific probiotics may have better efficacy for AD, we …

Mechanical unloading impairs cytosolic calcium (Ca2+) homeostasis in skeletal muscles. In
this study, we investigated whether sarco (endo) plasmic reticulum Ca2+-ATPase (SERCA) …

The muscle-specific RING-finger protein MuRF1 (also known as TRIM63) constitutes a bona
fide ubiquitin ligase that routes proteins like several different myosin heavy chain proteins …

Introduction As a post-translational modification, glycosylation plays vital role in regulating
the folding and function of proteins necessary for many biological processes. Unlike …

Glucocorticoids are frequently used as anti-inflammatory and immunosuppressive agents.
However, high doses and/or prolonged use induce undesired secondary effects such as …

Skeletal muscle atrophy as a consequence of acute and chronic illness, immobilisation,
muscular dystrophies and aging, leads to severe muscle weakness, inactivity and increased …