Cardiac lymphatics in health and disease

E Brakenhielm, K Alitalo - Nature Reviews Cardiology, 2019 - nature.com
The lymphatic vasculature, which accompanies the blood vasculature in most organs, is
indispensable in the maintenance of tissue fluid homeostasis, immune cell trafficking, and …

[HTML][HTML] T2-weighted cardiovascular magnetic resonance in acute cardiac disease

I Eitel, MG Friedrich - Journal of Cardiovascular Magnetic Resonance, 2011 - Elsevier
Cardiovascular magnetic resonance (CMR) using T2-weighted sequences can visualize
myocardial edema. When compared to previous protocols, newer pulse sequences with …

Selective stimulation of cardiac lymphangiogenesis reduces myocardial edema and fibrosis leading to improved cardiac function following myocardial infarction

O Henri, C Pouehe, M Houssari, L Galas, L Nicol… - Circulation, 2016 - Am Heart Assoc
Background—The lymphatic system regulates interstitial tissue fluid balance, and lymphatic
malfunction causes edema. The heart has an extensive lymphatic network displaying a …

Myocardial microvascular permeability, interstitial oedema, and compromised cardiac function

RM Dongaonkar, RH Stewart, HJ Geissler… - Cardiovascular …, 2010 - academic.oup.com
The heart, perhaps more than any other organ, is exquisitely sensitive to increases in
microvascular permeability and the accumulation of myocardial interstitial oedema fluid …

Pathophysiology and pathogenesis of post-resuscitation myocardial stunning

A Chalkias, T Xanthos - Heart failure reviews, 2012 - Springer
The prognosis for cardiac arrest victims remains dismal, as only 17% survives to hospital
discharge. Post-resuscitation myocardial stunning is the mechanical dysfunction that …

Cardiac troponin release following coronary artery bypass grafting: mechanisms and clinical implications

S Heuts, C Gollmann-Tepeköylü… - European Heart …, 2023 - academic.oup.com
The use of biomarkers is undisputed in the diagnosis of primary myocardial infarction (MI),
but their value for identifying MI is less well studied in the postoperative phase following …

Enhancement of cardiac lymphangiogenesis by transplantation of CD34+VEGFR-3+ endothelial progenitor cells and sustained release of VEGF-C

H Zhang, Y Wang, Y Tan, H Wang, P Tao… - Basic Research in …, 2019 - Springer
Impairment of cardiac lymphatic vessels leads to cardiac lymphedema. Recent studies have
suggested that stimulation of lymphangiogenesis may reduce cardiac lymphedema …

The ebb and flow of cardiac lymphatics: a tidal wave of new discoveries

NR Harris, L Bálint, DM Dy, NR Nielsen… - Physiological …, 2023 - journals.physiology.org
The heart is imbued with a vast lymphatic network that is responsible for fluid homeostasis
and immune cell trafficking. Disturbances in the forces that regulate microvascular fluid …

Myocardial fluid balance

U Mehlhorn, HJ Geissler, GA Laine… - European journal of …, 2001 - academic.oup.com
Fluid accumulation in the cardiac interstitium or myocardial edema is a common
manifestation of many clinical states. Specifically, cardiac surgery includes various …

Lymphangiogenic therapy prevents cardiac dysfunction by ameliorating inflammation and hypertension

LJ Song, X Chen, TA Swanson, B LaViolette, J Pang… - Elife, 2020 - elifesciences.org
The lymphatic vasculature is involved in the pathogenesis of acute cardiac injuries, but little
is known about its role in chronic cardiac dysfunction. Here, we demonstrate that …