Protein toxicity can be defined as all the pathological changes that ensue from
accumulation, mis-localization, and/or multimerization of disease-specific proteins. Most …

It is well established that the regulation of epigenetic factors, including chromatic
reorganization, histone modifications, DNA methylation, and miRNA regulation, is critical for …

N 6-methyladenosine (m6A) RNA methylation is the most abundant modification on mRNAs
and plays important roles in various biological processes. The formation of m6A is catalyzed …

Psychiatric disorders are complex multifactorial illnesses involving chronic alterations in
neural circuit structure and function. While genetic factors are important in the etiology of …

Although p300 and CBP lysine acetyltransferases are often treated interchangeably, the
inability of one enzyme to compensate for the loss of the other suggests unique roles for …

Neuropsychiatric pathologies, including neurodegenerative diseases and
neurodevelopmental syndromes, are frequently associated with dysregulation of various …

Alcohol use disorder (AUD) is a complex brain disorder with an array of persistent
behavioral and neurochemical manifestations. Both genetic and environmental factors are …

Exposure to alcohol has serious consequences for the developing fetus, leading to a range
of conditions collectively known as fetal alcohol spectrum disorders (FASD). Most …

Adverse in utero events can alter the development and function of numerous physiological
systems, giving rise to lasting neurodevelopmental deficits. In particular, data have shown …

Attention-deficit/hyperactivity disorder (ADHD) is a common childhood-onset
neurodevelopmental disorder characterised by persistent inattention, hyperactivity and …