Down the membrane hole: Ion channels in protozoan parasites

V Jimenez, S Mesones - PLoS pathogens, 2022 - journals.plos.org
Parasitic diseases caused by protozoans are highly prevalent around the world,
disproportionally affecting developing countries, where coinfection with other …

[HTML][HTML] Ion binding with charge inversion combined with screening modulates DEAD box helicase phase transitions

MD Crabtree, J Holland, AS Pillai, PS Kompella, L Babl… - Cell Reports, 2023 - cell.com
Membraneless organelles, or biomolecular condensates, enable cells to compartmentalize
material and processes into unique biochemical environments. While specific, attractive …

Antioxidant Nanoparticles Restore Cisplatin-Induced Male Fertility Defects by Promoting MDC1-53bp1-Associated Non-Homologous DNA Repair Mechanism and …

YS Wei, YL Chen, WY Li, YY Yang, SJ Lin… - International Journal …, 2023 - Taylor & Francis
Introduction Cisplatin, a commonly used anticancer compound, exhibits severe off-target
organ toxicity. Due to its wide application in cancer treatment, the reduction of its damage to …

Cytosolic and Acrosomal pH Regulation in Mammalian Sperm

JC Chávez, G Carrasquel-Martínez… - Cells, 2024 - mdpi.com
As in most cells, intracellular pH regulation is fundamental for sperm physiology. Key sperm
functions like swimming, maturation, and a unique exocytotic process, the acrosome …

In vitro aging of stallion spermatozoa during prolonged storage at 5 C

M Umair, A Claes, M Buijtendorp… - Cytometry Part …, 2023 - Wiley Online Library
Artificial insemination with chilled stallion semen is hampered by a limited period of
maximum fertility maintenance (24–48 h). This study used multiparametric flow cytometry to …

Sperm interaction with bacteria induces the spontaneous acrosome reaction

Y Azoulay, Z Malik, H Breitbart - Theriogenology, 2023 - Elsevier
Bacterial contamination in the semen deteriorates spermatozoa function. One mechanism
through which this may occur is by inducing a premature form of the acrosome reaction …

[HTML][HTML] Microcystin leucine arginine induces human sperm damage: Involvement of the Ca2+/CaMKKβ/AMPK pathway

X Guo, R Meng, J Liu, S Zhang, H Liu, X Du… - Ecotoxicology and …, 2023 - Elsevier
As a common pollutant in the water environment, microcystin leucine arginine (MC-LR) can
enter semen and damage the sperm in animals. However, the mechanism by which MC-LR …

Paternal obesity induces subfertility in male offspring by modulating the oxidative stress-related transcriptional network

L Li, Y Ma, C Zhu, Y Li, H Cao, Z Wu, T Jin… - International Journal of …, 2024 - nature.com
Background/objective The effects of fathers' high-fat diet (HFD) on the reproductive health of
their male offspring (HFD-F1) remain to be elucidated. Parental obesity is known to have a …

[PDF][PDF] Modalities of cell death, survival and adaptation: The role of the Ca2+-signaling toolkit

JB Parys, G Bultynck - Cell Calcium, 2023 - lirias.kuleuven.be
It is well-established that intracellular Ca2+ plays a central role in cell death, survival and
adaptation decisions, including, but not limited to, fertilization [1, 2], modulation of …

Sodium Hexametaphosphate Serves as an Inducer of Calcium Signaling

D Katano, W Kang, Y Harada, N Kawano, M Miyado… - Biomolecules, 2023 - mdpi.com
In bacteria, polymers of inorganic phosphates, particularly linear polyphosphate, are used
as alternative phosphate donors for adenosine triphosphate production. A six-chain form of …