[HTML][HTML] Platinum-based drugs for cancer therapy and anti-tumor strategies
C Zhang, C Xu, X Gao, Q Yao - Theranostics, 2022 - ncbi.nlm.nih.gov
Platinum-based drugs cisplatin, carboplatin, and oxaliplatin are widely used for
chemotherapeutic eradication of cancer. However, the side effects of platinum drugs, such …
chemotherapeutic eradication of cancer. However, the side effects of platinum drugs, such …
Organometallic anti-tumor agents: targeting from biomolecules to dynamic bioprocesses
The great clinical success of cisplatin and its derivatives has convinced people that metal
complexes could play a more significant role in human cancer therapy. However, targeting …
complexes could play a more significant role in human cancer therapy. However, targeting …
Metabolism of amino acids in cancer
Metabolic reprogramming has been widely recognized as a hallmark of malignancy. The
uptake and metabolism of amino acids are aberrantly upregulated in many cancers that …
uptake and metabolism of amino acids are aberrantly upregulated in many cancers that …
Latest developments in metal complexes as anticancer agents
R Paprocka, M Wiese-Szadkowska… - Coordination Chemistry …, 2022 - Elsevier
Every year novel biologically active compounds are designed as antitumor agents. This
review covers and highlights some of the most important findings described during 2018 …
review covers and highlights some of the most important findings described during 2018 …
What blocks more anticancer platinum complexes from experiment to clinic: Major problems and potential strategies from drug design perspectives
K Peng, BB Liang, W Liu, ZW Mao - Coordination Chemistry Reviews, 2021 - Elsevier
Encouraged by the worldwide success of cisplatin in the field of cancer chemotherapy,
intensive works have been conducted to explore more platinum coordination complexes as …
intensive works have been conducted to explore more platinum coordination complexes as …
Thermal proteome profiling for interrogating protein interactions
Thermal proteome profiling (TPP) is based on the principle that, when subjected to heat,
proteins denature and become insoluble. Proteins can change their thermal stability upon …
proteins denature and become insoluble. Proteins can change their thermal stability upon …
Recent advances in identifying protein targets in drug discovery
Phenotype-based screening has emerged as an alternative route for discovering new
chemical entities toward first-in-class therapeutics. However, clarifying their mode of action …
chemical entities toward first-in-class therapeutics. However, clarifying their mode of action …
Target profiling of an iridium (III)-based immunogenic cell death inducer unveils the engagement of unfolded protein response regulator BiP
Clinical chemotherapeutic drugs have occasionally been observed to induce antitumor
immune responses beyond the direct cytotoxicity. Such effects are coined as immunogenic …
immune responses beyond the direct cytotoxicity. Such effects are coined as immunogenic …
PlatinER: A highly potent anticancer platinum (II) complex that induces endoplasmic reticulum stress driven immunogenic cell death
Immunogenic cell death (ICD) is a rare immunostimulatory form of cell death that can
improve the clinical outcomes of chemo‐immunotherapeutic combination regimens through …
improve the clinical outcomes of chemo‐immunotherapeutic combination regimens through …
Asparagine synthetase in cancer: beyond acute lymphoblastic leukemia
M Chiu, G Taurino, MG Bianchi, MS Kilberg… - Frontiers in …, 2020 - frontiersin.org
Asparagine Synthetase (ASNS) catalyzes the synthesis of the non-essential amino acid
asparagine (Asn) from aspartate (Asp) and glutamine (Gln). ASNS expression is highly …
asparagine (Asn) from aspartate (Asp) and glutamine (Gln). ASNS expression is highly …