The granule exocytosis pathway of cytotoxic lymphocytes is crucial for immune surveillance
and homeostasis. The trafficking of granule components, including the membrane-disruptive …

The breakdown of mechanisms assuring the recognition of self and non‐self is a hallmark
feature of autoimmune diseases. In the past 10 years, there has been a steadily increasing …

Cytotoxic T lymphocytes and natural killer cells use the perforin/granzyme pathway to kill
virally infected cells and tumor cells. Mutations in genes important for this pathway are …

Hemophagocytic lymphohistiocytosis (HLH) is a rare disorder with familial and acquired
forms. The familial form is associated with mutations in the perforin gene and both forms are …

Cytotoxic T lymphocyte and natural killer cell-initiated cell death is one of the primary
mechanisms used by higher organisms to eliminate viruses and transformed cells. In this …

Efficient boosting of memory T-cell numbers to protective levels generally requires a
relatively long interval between immunizations. Decreasing this interval could be crucial in …

Pathogen-specific CD8+ T cells expand in number after infection and then their numbers
invariably contract by 90–95%, leaving a stable memory cell pool. The chief features of this …

Familial haemophagocytic lymphohistiocytosis (FHL) is a rare autosomal recessive disorder
of immune dysregulation associated with uncontrolled T cell and macrophage activation and …

Memory CD8 T cells can provide protection from re-infection by respiratory viruses such as
influenza and SARS. However, the relative contribution of memory CD8 T cells in providing …

Hemophagocytic lymphohistiocytosis (HLH) is a rare life‐threatening disease in which the
immune system becomes overactive due to its inability to effectively respond to infections …