Ribosome biogenesis and protein synthesis are fundamental rate-limiting steps for cell
growth and proliferation. The ribosomal proteins (RPs), comprising the structural parts of the …

Ribosomal RNAs are the most abundant and universal noncoding RNAs in living organisms.
In eukaryotes, three of the four ribosomal RNAs forming the 40S and 60S subunits are borne …

Importance Osteosarcoma, the most common malignant bone tumor in children and
adolescents, occurs in a high number of cancer predisposition syndromes that are defined …

Advances in sequencing and high-throughput techniques have provided an unprecedented
opportunity to interrogate human diseases on a genome-wide scale. The list of disease …

Mature ribosomal RNAs (rRNAs) are produced from polycistronic precursors following
complex processing. Precursor (pre)-rRNA processing has been extensively characterized …

Regulation of mRNA translation offers the opportunity to diversify the expression and
abundance of proteins made from individual gene products in cells, tissues and organisms …

Abstract Background The history of African indigenous cattle and their adaptation to
environmental and human selection pressure is at the root of their remarkable diversity …

Ribosomal protein haploinsufficiency occurs in diverse human diseases including Diamond-
Blackfan anemia (DBA),, congenital asplenia and T cell leukemia. Yet, how mutations in …

A veritable explosion of primary research papers within the past 10 years focuses on
nucleolar and ribosomal stress, and for good reason: with ribosome biosynthesis …

Mutations that target the ubiquitous process of ribosome assembly paradoxically cause
diverse tissue-specific disorders (ribosomopathies) that are often associated with an …