The prenatal period is increasingly considered as a crucial target for the primary prevention
of neurodevelopmental and psychiatric disorders. Understanding their pathophysiological …

Highlights•Sensitive periods in humans are studied using methods developed in animal
models•Environmental deprivation is the predominant approach to studying sensitive …

Human neurodevelopment requires the organization of neural elements into complex
structural and functional networks called the connectome. Emerging data suggest that …

When considering neurodevelopmental disorders (NDDs), Schizophrenia (SZ) and Autism
Spectrum Disorder (ASD) are considered to be among the most severe in term of …

Parvalbumin (PV) is a calcium binding protein expressed by inhibitory fast-spiking
interneurons in the cerebral cortex. By generating a fast stream of action potentials, PV+ …

Risk for neuropsychiatric disorders is complex and includes an individual's internal genetic
endowment and their environmental experiences and exposures. Embryonic development …

Prenatal stress exposure is associated with adverse psychiatric outcomes, including autism
and ADHD, as well as locomotor and social inhibition and anxiety-like behaviors in animal …

Adolescence is a window of vulnerability to environmental factors such as chronic stress that
can disrupt brain development and cause long-lasting behavioral dysfunction, as seen in …

Maternal depressive symptoms during pregnancy are associated with risk for offspring
emotional and behavioral problems, but the mechanisms by which this association occurs …

Stress-related psychiatric disorders including depression involve complex cellular and
molecular changes in the brain, and GABAergic signaling dysfunction is increasingly …