Significance: Cell senescence was originally defined by an acute loss of replicative capacity
and thus believed to be restricted to proliferation-competent cells. More recently …

Ageing is the biggest risk factor for impaired cardiovascular health, with cardiovascular
disease being the cause of death in 40% of individuals over 65 years old. Ageing is …

The adult mammalian heart is non-regenerative owing to the post-mitotic nature of
cardiomyocytes. The neonatal mouse heart can regenerate, but only during the first week of …

Ageing is the biggest risk factor for cardiovascular disease. Cellular senescence, a process
driven in part by telomere shortening, has been implicated in age‐related tissue dysfunction …

Replicative capacity of somatic cells is limited. It indicates that aging also develops at the
cellular level, and this is described as “cellular senescence”. Senescent cells become …

A key component of cardiac ischemia–reperfusion injury (IRI) is the increased generation of
reactive oxygen species, leading to enhanced inflammation and tissue dysfunction in …

Shortened telomeres have been linked to numerous chronic diseases, most importantly
coronary artery disease, but the underlying mechanisms remain ill defined. Loss-of-function …

Ageing is the biggest risk factor for impaired cardiovascular health, with cardiovascular
disease being the leading cause of death in 40% of individuals over 65 years old. Ageing is …

Myocardial infarction is a leading cause of morbidity and mortality. While reperfusion is now
standard therapy, pathological remodelling leading to heart failure remains a clinical …

In the elderly population, pathological inflammation has been associated with ageing-
associated diseases. The term 'inflammageing', which was used for the first time by …