Immunoglobulin A (IgA) plays a key role in defending mucosal surfaces against attack by
infectious microorganisms. Such sites present a major site of susceptibility due to their vast …

Immunoglobulin A (IgA) is the most abundant antibody class present at mucosal surfaces.
The production of IgA exceeds the production of all other antibodies combined, supporting …

Here we discuss recent advances in understanding the biochemical, immunologic, and
genetic pathogenesis of IgA nephropathy, the most common primary glomerulonephritis …

The vast surfaces of the gastrointestinal, respiratory, and genitourinary tracts represent
major sites of potential attack by invading micro‐organisms. Immunoglobulin A (IgA), as the …

Immunoglobulin A (IgA) has a critical role in immune defense particularly at the mucosal
surfaces, and is equipped to do so by the unique structural attributes of its heavy chain and …

Activation of the humoral immune system is initiated when antibodies recognize an antigen
and trigger effector functions through the interaction with Fc engaging molecules. The most …

Secretory antibodies of the immunoglobulin A (IgA) class form the first line of antigen‐
specific immune protection against inhaled, ingested, and sexually transmitted pathogens …

The direct or indirect targeting of antibody Fc receptors (FcRs) presents unique opportunities
and interesting challenges for the treatment of inflammatory diseases, cancer and infection …

Secretory immunoglobulin A (sIgA) represents the immune system's first line of defense
against mucosal pathogens. IgAs are transported across the epithelium, as dimers and …

Immunoglobulins couple the recognition of invading pathogens with the triggering of potent
effector mechanisms for pathogen elimination. Different immunoglobulin classes trigger …