Evolving therapeutic landscape of advanced hepatocellular carcinoma

C Yang, H Zhang, L Zhang, AX Zhu… - Nature reviews …, 2023 - nature.com
Hepatocellular carcinoma (HCC) is one of the most common solid malignancies worldwide.
A large proportion of patients with HCC are diagnosed at advanced stages and are only …

Advances in immunotherapy for hepatocellular carcinoma

B Sangro, P Sarobe, S Hervás-Stubbs… - Nature reviews …, 2021 - nature.com
Hepatocellular carcinoma (HCC) is a prevalent disease with a progression that is modulated
by the immune system. Systemic therapy is used in the advanced stage and until 2017 …

Cytokines in the treatment of cancer

KC Conlon, MD Miljkovic… - Journal of Interferon & …, 2019 - liebertpub.com
Cytokines are major regulators of innate and adaptive immunity that enable cells of the
immune system to communicate over short distances. Cytokine therapy to activate the …

Immunotherapy for hepatocellular carcinoma: current status and future prospects

Z Liu, X Liu, J Liang, Y Liu, X Hou, M Zhang… - Frontiers in …, 2021 - frontiersin.org
Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer with poor
prognosis. Surgery, chemotherapy, and radiofrequency ablation are three conventional …

Tumor-infiltrating lymphocytes for treatment of solid tumors: It takes two to tango?

MH Kazemi, M Sadri, A Najafi, A Rahimi… - Frontiers in …, 2022 - frontiersin.org
Tumor-infiltrating lymphocytes (TILs), frontline soldiers of the adaptive immune system, are
recruited into the tumor site to fight against tumors. However, their small number and …

[HTML][HTML] Immunotherapy for hepatocellular carcinoma: Current status and future perspectives

DS Mandlik, SK Mandlik… - World Journal of …, 2023 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is one of the world's deadliest and fastest-growing tumors,
with a poor prognosis. HCC develops in the context of chronic liver disease. Curative …

CD8+ T cell exhaustion and cancer immunotherapy

Q Wang, Y Qin, B Li - Cancer letters, 2023 - Elsevier
Immunotherapy plays an increasingly important role in the treatment of most malignant
tumors, and CD8+ T cells are the most important antitumor effector cells in the process of …

CAR-T cells and BiTEs in solid tumors: challenges and perspectives

J Edeline, R Houot, A Marabelle… - Journal of Hematology & …, 2021 - Springer
Chimeric antigen receptor (CAR)-modified T cells and BiTEs are both immunotherapies
which redirect T cell specificity against a tumor-specific antigen through the use of antibody …

The immunology of hepatocellular carcinoma

G Lawal, Y Xiao, AA Rahnemai-Azar, DI Tsilimigras… - Vaccines, 2021 - mdpi.com
Liver cancer is the third leading cause of cancer death worldwide. Hepatocellular carcinoma
(HCC) is the most common primary malignant tumor of the liver. Liver resection or …

Immunotherapy for hepatocellular carcinoma: a 2021 update

C Kole, N Charalampakis, S Tsakatikas, M Vailas… - Cancers, 2020 - mdpi.com
Simple Summary Hepatocellular carcinoma (HCC) is the most common liver malignancy
associated with poor prognosis. Treatment options are limited partially due to resistance to …