Skeletal muscle oxidative stress and inflammation in aging: Focus on antioxidant and anti-inflammatory therapy

M Chen, Y Wang, S Deng, Z Lian, K Yu - Frontiers in Cell and …, 2022 - frontiersin.org
With aging, the progressive loss of skeletal muscle will have negative effect on multiple
physiological parameters, such as exercise, respiration, thermoregulation, and metabolic …

Mitochondrial impairment in sarcopenia

F Bellanti, A Lo Buglio, G Vendemiale - Biology, 2021 - mdpi.com
Simple Summary With old age, the strength and size of our muscles worsens with time,
affecting our ability to carry out daily activities. Muscle wasting may be more dangerous for …

[PDF][PDF] lo Buglio

F Bellanti, AD Romano - 2021 - academia.edu
Safety of healthcare workers in hospitals is a major concern during the COVID-19 pandemic.
Being exposed for several working hours per day to infected patients, nurses dealing with …

Early myopathy in Duchenne muscular dystrophy is associated with elevated mitochondrial H2O2 emission during impaired oxidative phosphorylation

MC Hughes, SV Ramos, PC Turnbull… - Journal of cachexia …, 2019 - Wiley Online Library
Background Muscle wasting and weakness in Duchenne muscular dystrophy (DMD) causes
severe locomotor limitations and early death due in part to respiratory muscle failure. Given …

[HTML][HTML] Reduced mitochondrial lipid oxidation leads to fat accumulation in myosteatosis

JP Gumucio, AH Qasawa, PJ Ferrara, AN Malik… - The FASEB …, 2019 - ncbi.nlm.nih.gov
Myosteatosis is the pathologic accumulation of lipid that can occur in conjunction with
atrophy and fibrosis following skeletal muscle injury. Little is known about the mechanisms …

Redox signaling and sarcopenia: searching for the primary suspect

NA Foreman, AS Hesse, LL Ji - International journal of molecular sciences, 2021 - mdpi.com
Sarcopenia, the age-related decline in muscle mass and function, derives from multiple
etiological mechanisms. Accumulative research suggests that reactive oxygen species …

Regulation of bone by mechanical loading, sex hormones, and nerves: Integration of such regulatory complexity and implications for bone loss during space flight and …

DA Hart - Biomolecules, 2023 - mdpi.com
During evolution, the development of bone was critical for many species to thrive and
function in the boundary conditions of Earth. Furthermore, bone also became a storehouse …

Muscle delivery of mitochondria-targeted drugs for the treatment of sarcopenia: rationale and perspectives

F Bellanti, A Lo Buglio, G Vendemiale - Pharmaceutics, 2022 - mdpi.com
An impairment in mitochondrial homeostasis plays a crucial role in the process of aging and
contributes to the incidence of age-related diseases, including sarcopenia, which is defined …

Mitochondria as nutritional targets to maintain muscle health and physical function during ageing

SC Broome, J Whitfield, LG Karagounis, JA Hawley - Sports Medicine, 2024 - Springer
The age-related loss of skeletal muscle mass and physical function leads to a loss of
independence and an increased reliance on health-care. Mitochondria are crucial in the …

[HTML][HTML] Exercise-induced adaptations to homeostasis of reactive oxygen species in skeletal muscle

MJ Jackson - Free Radical Biology and Medicine, 2024 - Elsevier
Reactive oxygen species are generated by multiple mechanisms during contractile activity in
exercising skeletal muscle and are recognised to play a role in signaling adaptations to the …