Colorectal cancer (CRC) is a leading cause of cancer morbidity and mortality worldwide.
The etiology and pathogenesis of CRC remain unclear. A growing body of evidence …

Tryptophan (Trp) functions in host-disease interactions. Its metabolism is a multi-pathway
process. Indole and its derivatives are Trp metabolites unique to the human gut microbiota …

Background Amino acid metabolism is dysregulated in colorectal cancer patients; however,
it is not clear whether pre-diagnostic levels of amino acids are associated with subsequent …

Background Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide,
but if discovered at an early stage, the survival rate is high. The aim of this study was to …

Background. The screening and early detection of colorectal cancer (CRC) still remain a
challenge due to the lack of reliable and effective serum biomarkers. Thus, this study is …

Abstract BACKGROUND Food polysaccharide 1, 3‐β‐d‐glucan (OBG) has been shown to
alleviate ulcerative colitis (UC) in a mouse model, but the underlying mechanisms remain …

Recently, mesoporous nanomaterials with widespread applications have attracted great
interest in the field of drug delivery due to their unique structure and good physiochemical …

Background Epidemiological studies of associations between metabolites and cancer risk
have typically focused on specific cancer types separately. Here, we designed a multivariate …

Alterations within the tryptophan–kynurenine metabolic pathway have been linked to the
etiology of colorectal cancer (CRC), but the relevance of this pathway for prognostic …

Objective To investigate host and gut-microbiota related Tryptophan metabolism in hand
osteoarthritis (HOA). Methods The baseline serum concentration of 20 Tryptophan …