Medications to treat disease and extend life in our patients often amass in quantities,
resulting in what has been termed “polypharmacy.” This imprecise label usually describes …

Aging is known to be associated with an increased prevalence of multiple chronic diseases,
which frequently causes the use of complex therapeutic regimens. The aging process is …

Background Despite the high intake of medications with anticholinergic properties by
community-dwelling elderly persons, the effects on cognitive decline and dementia have …

BACKGROUND: Elderly patients are vulnerable to drug interactions because of age-related
physiologic changes, an increased risk for disease associated with aging, and the …

The rising of global geriatric population has contributed to increased prevalence of
dementia. Dementia is a neurodegenerative disease, which is characterized by progressive …

Delayed awakening from anesthesia remains one of the biggest challenges that involve an
anesthesiologist. With the general use of fast-acting anesthetic agents, patients usually …

Objective To examine associations between gabapentinoids and adverse outcomes related
to coordination disturbances (head or body injuries, or both and road traffic incidents or …

Introduction: Anticholinergics are a class of medicines that block the neurotransmitter,
acetylcholine, in the brain and peripheral tissues. Medicines with anticholinergic activity are …

Adverse drug reactions (ADRs) represent a major burden on society, resulting in significant
morbidity, mortality, and health care costs. Older patients living in the community are …

In people who are aged> 65 years, pharmacokinetics are influenced more by the loss of
kidney function than by the aging process of any other organ. A GFR of 30 to 60 ml/min …