Nature achieves differentiation of specific and nonspecific binding in molecular interactions
through precise control of biomolecules in space and time. Artificial systems such as …

The growing importance of peptides and proteins in therapeutic and biomedical applications
has provided immense motivation toward the development of new ways to construct and …

Background: STIM1 and Orai1, reconstituting a main cellular Ca 2+ entry pathway, interact
via their cytosolic strands. Results: The extended transmembrane Orai1 N-terminal (ETON) …

Fundamental processes in living cells are largely controlled by macromolecular interactions
and among them, protein protein interactions (PPIs) have a critical role while their …

Introduction Protein thermostability is an important field for its evolutionary perspective of
mesophilic versus thermophilic relationship and for its industrial/therapeutic applications …

The dog has assumed a prominent role in human society. Associated with that status, diet
choices for companion dogs have begun to reflect the personal preferences of the owners …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the
degeneration of both upper and lower motor neurons in the brain and spinal cord. ALS is …

Protein–protein interactions (PPIs) are carrying out diverse functions in living systems and
are playing a major role in the health and disease states. Low molecular weight (LMW)“drug …

Protein–protein interactions (PPIs) are essential, and modulating their function through PPI-
targeted drugs is an important research field. PPI sites are shallow protein surfaces readily …

The data from protein structures from the Protein Data Bank and quantum chemical
calculations indicate the importance of aromatic–aromatic interactions at large horizontal …