▪ Abstract Ubiquitous among eukaryotes, the ADF/cofilins are essential proteins responsible
for the high turnover rates of actin filaments in vivo. In vertebrates, ADF and cofilin are …

The actin-depolymerizing factor (ADF)/cofilins are a family of essential actin regulatory
proteins, ubiquitous among eukaryotes, that enhance the turnover of actin by regulating the …

Mutations in anc-1 (nuclear anchorage defective) disrupt the positioning of nuclei and
mitochondria in Caenorhabditis elegans. ANC-1 is shown to consist of mostly coiled regions …

Actin-depolymerizing factor (ADF)/cofilins are small actin-binding proteins found in all
eukaryotes. In vitro, ADF/cofilins promote actin dynamics by depolymerizing and severing …

The actin cytoskeleton is one of the major structural components of the cell. It often
undergoes rapid reorganization and plays crucial roles in a number of dynamic cellular …

ADF/cofilins are key regulators of actin dynamics in normal cells. Recent findings suggest
that, under cellular stress, the wild-type proteins might form complexes with actin that can …

Actin-depolymerizing factor (ADF)/cofilins are essential regulators of actin filament turnover.
Several ADF/cofilin isoforms are found in multicellular organisms, but their biological …

Cofilin/ADF proteins are a ubiquitously expressed family of F-actin depolymerizing factors
found in eukaryotic cells including plants. In vitro, cofilin/ADF activity has been shown to be …

Nemaline myopathy (NM) is a congenital myopathy characterized by muscle weakness and
nemaline bodies in affected myofibers. Five NM genes, all encoding components of the …

Tropomyosin binds to actin filaments and is implicated in stabilization of actin cytoskeleton.
We examined biochemical and cell biological properties of Caenorhabditis elegans …