G protein–coupled receptors (GPCRs) are a superfamily of transmembrane signal
transducers that facilitate the flow of chemical signals across membranes. GPCRs are a …

The field of pharmacogenetics, the investigation of the influence of one or more sequence
variants on drug response phenotypes, is a special case of pharmacogenomics, a discipline …

ABSTRACT G protein-coupled receptors (GPCRs) are the largest class of transmembrane
receptors encoded in the human genome, and they initiate cellular responses triggered by a …

G protein-coupled receptors (GPCRs) are pivotal in mediating diverse physiological and
pathological processes, rendering them promising targets for drug discovery. GPCRs …

In the nervous system, G protein-coupled receptors (GPCRs) control neuronal excitability,
synaptic transmission, synaptic plasticity, and, ultimately, behavior through spatiotemporally …

G protein-coupled receptors (GPCRs) represent the largest family of cell membrane 10
receptors, encompassing over 800 members in humans. These receptors play a pivotal role …

ABSTRACT G protein-coupled receptor (GPCR) signalling pathways underlie numerous
physiological processes, are implicated in many diseases and are major targets for …

G protein-coupled receptors (GPCRs) represent some of the most important drug targets in
the human genome, however, our understanding of these receptors has primarily been …

Phenotypic drug discovery (PDD) involves screening compounds for their effects on cells,
tissues, or whole organisms without necessarily understanding the underlying molecular …

Bioluminescence-and fluorescence-based resonance energy transfer assays have gained
considerable attention in pharmacological research as high-throughput scalable tools …