Redox-directed cancer therapeutics: molecular mechanisms and opportunities

GT Wondrak - Antioxidants & redox signaling, 2009 - liebertpub.com
Redox dysregulation originating from metabolic alterations and dependence on mitogenic
and survival signaling through reactive oxygen species represents a specific vulnerability of …

[HTML][HTML] Regulation of mitochondrial respiratory chain biogenesis by estrogens/estrogen receptors and physiological, pathological and pharmacological implications

JQ Chen, PR Cammarata, CP Baines… - Biochimica et Biophysica …, 2009 - Elsevier
There has been increasing evidence pointing to the mitochondrial respiratory chain (MRC)
as a novel and important target for the actions of 17β-estradiol (E2) and estrogen receptors …

A model of the mitochondrial basis of bipolar disorder

G Morris, K Walder, SL McGee, OM Dean… - Neuroscience & …, 2017 - Elsevier
Background Bipolar disorder phenomenologically is a biphasic disorder of energy
availability; increased in mania and decreased in depression. In consort, there is …

Reactive Oxygen Species Production and Mitochondrial Dysfunction Contribute to Quercetin Induced Death in Leishmania amazonensis

F Fonseca-Silva, JDF Inacio, MM Canto-Cavalheiro… - PloS one, 2011 - journals.plos.org
Background Leishmaniasis, a parasitic disease caused by protozoa of the genus
Leishmania, affects more than 12 million people worldwide. Quercetin has generated …

NLRP3 inflammasome activation induced by engineered nanomaterials

B Sun, X Wang, Z Ji, R Li, T Xia - Small, 2013 - Wiley Online Library
Engineered nanomaterials (ENMs) continue to attract significant attention because they
have novel physicochemical properties that can improve the functions of products that will …

[HTML][HTML] Studies on green synthesized silver nanoparticles using Abelmoschus esculentus (L.) pulp extract having anticancer (in vitro) and antimicrobial applications

MMR Mollick, D Rana, SK Dash… - Arabian journal of …, 2019 - Elsevier
Abstract Silver nanoparticles (Ag NPs) were successfully synthesized using AgNO 3 via an
eco-friendly and simple green route using Abelmoschus esculentus (L.) pulp extract at room …

Mitochondrial calpain-1 disrupts ATP synthase and induces superoxide generation in type 1 diabetic hearts: a novel mechanism contributing to diabetic …

R Ni, D Zheng, S Xiong, DJ Hill, T Sun, RB Gardiner… - Diabetes, 2016 - Am Diabetes Assoc
Calpain plays a critical role in cardiomyopathic changes in type 1 diabetes (T1D). This study
investigated how calpain regulates mitochondrial reactive oxygen species (ROS) generation …

Attenuation of multi-targeted proliferation-linked signaling by 3, 3′-diindolylmethane (DIM): from bench to clinic

S Banerjee, D Kong, Z Wang, B Bao, GG Hillman… - … Research/Reviews in …, 2011 - Elsevier
Emerging evidence provide credible support in favor of the potential role of bioactive
products derived from ingesting cruciferous vegetables such as broccoli, brussel sprouts …

The double‐edged sword in pathogenic trypanosomatids: the pivotal role of mitochondria in oxidative stress and bioenergetics

RFS Menna-Barreto… - BioMed research …, 2014 - Wiley Online Library
The pathogenic trypanosomatids Trypanosoma brucei, Trypanosoma cruzi, and Leishmania
spp. are the causative agents of African trypanosomiasis, Chagas disease, and …

Novel cell‐penetrating peptide targeting mitochondria

CP Cerrato, M Pirisinu, EN Vlachos… - The FASEB …, 2015 - Wiley Online Library
Cell‐penetrating peptides (CPPs) are short, nontoxic peptides with cationic and/or
amphipathic properties able to cross the cellular membrane. CPPs are used for the delivery …