Natural extracts for antibacterial applications

C Chen, L Chen, C Mao, L Jin, S Wu, Y Zheng, Z Cui… - Small, 2024 - Wiley Online Library
Bacteria‐induced epidemics and infectious diseases are seriously threatening the health of
people around the world. In addition, antibiotic therapy has been inducing increasingly more …

Unrealized targets in the discovery of antibiotics for gram-negative bacterial infections

U Theuretzbacher, B Blasco, M Duffey… - Nature Reviews Drug …, 2023 - nature.com
Advances in areas that include genomics, systems biology, protein structure determination
and artificial intelligence provide new opportunities for target-based antibacterial drug …

A review of antibacterial candidates with new modes of action

MS Butler, W Vollmer, ECA Goodall… - ACS Infectious …, 2024 - ACS Publications
There is a lack of new antibiotics to combat drug-resistant bacterial infections that
increasingly threaten global health. The current pipeline of clinical-stage antimicrobials is …

Targeting LPS biosynthesis and transport in gram-negative bacteria in the era of multi-drug resistance

KP Romano, DT Hung - Biochimica et Biophysica Acta (BBA)-Molecular …, 2023 - Elsevier
Gram-negative bacteria pose a major threat to human health in an era fraught with multi-
drug resistant bacterial infections. Despite extensive drug discovery campaigns over the …

Lipopolysaccharide lipid A: A promising molecule for new immunity-based therapies and antibiotics

P Garcia-Vello, F Di Lorenzo, D Zucchetta… - Pharmacology & …, 2022 - Elsevier
Lipopolysaccharides (LPS) are the main components of the external leaflet of the Gram-
negative outer membrane and consist of three different moieties: lipid A, core …

Potential therapeutic targets of Klebsiella pneumoniae: a multi-omics review perspective

S Ali, M Alam, GM Hasan… - Briefings in functional …, 2022 - academic.oup.com
The multidrug resistance developed in many organisms due to the prolonged use of
antibiotics has been an increasing global health crisis. Klebsiella pneumoniae is a causal …

Discovery of Novel UDP-N-Acetylglucosamine Acyltransferase (LpxA) Inhibitors with Activity against Pseudomonas aeruginosa

MD Ryan, AL Parkes, D Corbett, AP Dickie… - Journal of Medicinal …, 2021 - ACS Publications
This study describes a novel series of UDP-N-acetylglucosamine acyltransferase (LpxA)
inhibitors that was identified through affinity-mediated selection from a DNA-encoded …

Development of fluorescent probes with specific recognition moiety for hydrogen polysulfide

X Zhang, Y Yang, L Zhang, S Liu, Z Song, L Zhang… - Talanta, 2024 - Elsevier
Hydrogen polysulfide (H 2 S n, n> 1) is an important component of reactive sulfur species
(RSS), which is an important substance for maintaining the redox balance in cells. However …

Bacterial metabolism and susceptibility to cell wall-active antibiotics

MR Keller, T Dörr - Advances in microbial physiology, 2023 - Elsevier
Bacterial infections are increasingly resistant to antimicrobial therapy. Intense research
focus has thus been placed on identifying the mechanisms that bacteria use to resist killing …

Structure-and ligand-dynamics-based design of novel antibiotics targeting lipid A enzymes LpxC and LpxH in Gram-negative bacteria

P Zhou, J Hong - Accounts of chemical research, 2021 - ACS Publications
Conspectus Bacterial infections caused by multi-drug-resistant Gram-negative pathogens
pose a serious threat to public health. Gram-negative bacteria are characterized by the …