Introduction Malaria, a devastating febrile illness caused by protozoan parasites, sickened
247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in …

In 1967, pioneering work by Ruth Nussenzweig demonstrated for the first time that irradiated
sporozoites of the rodent malaria parasite Plasmodium berghei protected mice against a …

Delivering macromolecules across biological barriers such as the blood–brain barrier limits
their application in vivo. Previous work has demonstrated that Toxoplasma gondii, a parasite …

Malaria is a global infectious disease that remains a leading cause of morbidity and mortality
in the developing world. Multiple environmental and host and parasite factors govern the …

Abstract Background Plasmodium falciparum (Pf) whole-organism sporozoite vaccines have
been shown to provide significant protection against controlled human malaria infection …

Despite the success of vaccines in preventing many infectious diseases, effective vaccines
against pathogens with ongoing challenges—such as HIV, malaria, and tuberculosis …

Though the immunity to malaria has been associated with cellular immune responses, the
exact function of the phenotypic cell population is still unclear. This study investigated the …

For some diseases, successful vaccines have been developed using a nonpathogenic
counterpart of the causative microorganism of choice. The nonpathogenicity of the rodent …

Malaria is a highly prevalent parasitic disease in regions with tropical and subtropical
climates worldwide. Among the species of Plasmodium causing human malaria, P. vivax is …

Plasmodium, the causative agent of malaria, is responsible for more than 200 million new
infections and 400 000 deaths yearly. While in recent years the influence of the microbiota in …