Monoclonal antibodies to the circumsporozoite proteins as an emerging tool for malaria prevention
Despite various public health strategies, malaria caused by Plasmodium falciparum
parasites remains a major global health challenge that requires development of new …
parasites remains a major global health challenge that requires development of new …
[HTML][HTML] Molecular determinants of cross-reactivity and potency by VH3-33 antibodies against the Plasmodium falciparum circumsporozoite protein
E Thai, R Murugan, Š Binter, CB Aschner, K Prieto… - Cell Reports, 2023 - cell.com
Summary IGHV3-33-encoded antibodies are prevalent in the human humoral response
against the Plasmodium falciparum circumsporozoite protein (PfCSP). Among VH3-33 …
against the Plasmodium falciparum circumsporozoite protein (PfCSP). Among VH3-33 …
Somatic hypermutation-mediated paratope flexibility improves the cross-reactivity of human malaria antibodies
R Murugan, A Hanke, OE Oludada, G Costa… - bioRxiv, 2024 - biorxiv.org
The protective capacity of antibodies targeting circumsporozoite protein on sporozoites of
the malaria parasite Plasmodium falciparum (PfCSP) is linked to high affinity and cross …
the malaria parasite Plasmodium falciparum (PfCSP) is linked to high affinity and cross …
Target-agnostic identification of human antibodies to Plasmodium falciparum sexual forms reveals cross stage recognition of glutamate-rich repeats
A Amen, R Yoo, A Fabra-García, J Bolscher… - bioRxiv, 2023 - biorxiv.org
Circulating sexual stages of Plasmodium falciparum (Pf) can be transmitted from humans to
mosquitoes, thereby furthering the spread of malaria in the population. It is well established …
mosquitoes, thereby furthering the spread of malaria in the population. It is well established …