Cardiac surgery is associated with perioperative blood loss and a high risk of allogeneic
blood transfusion. Patient blood management (PBM) in cardiac surgery contributes to the …

Bleeding after cardiac surgery is a common and serious complication leading to transfusion
of multiple blood products and resulting in increased morbidity and mortality. Despite the …

Owing to the constantly evolving nature of the medical literature, the Society of Thoracic
Surgeons (STS) clinical practice guidelines periodically undergoes evaluation and updating …

Background Severe traumatic injury continues to present challenges to healthcare systems
around the world, and post-traumatic bleeding remains a leading cause of potentially …

Background Severe trauma continues to represent a global public health issue and mortality
and morbidity in trauma patients remains substantial. A number of initiatives have aimed to …

Background Tranexamic acid reduces the risk of bleeding among patients undergoing
cardiac surgery, but it is unclear whether this leads to improved outcomes. Furthermore …

Document Reviewers: Moritz WV Wyler von Ballmoos (USA), Mate Petricevic (Croatia), Arie
Pieter Kappetein (Netherlands), Miguel Sousa-Uva (Portugal), Georg Trummer (Germany) …

Regulators consider randomized controlled trials (RCTs) as the gold standard for evaluating
the safety and effectiveness of medications, but their costs, duration, and limited …

Importance Tranexamic acid is recommended for reducing blood loss and transfusion in
cardiac surgery. However, it remains unknown whether a high dose of tranexamic acid …

Whenever possible, the recommendations listed in this document are evidence based.
Articles reviewed in this guideline revision covered evidence from the past 10 years through …