HIV tissue reservoirs: current advances in research

K Li, B Liu, R Ma, Q Zhang - AIDS patient care and STDs, 2023 - liebertpub.com
Acquired immunodeficiency syndrome (AIDS), caused by the human immunodeficiency
virus (HIV), has become a heavy burden of disease and an important public health problem …

Drug resistance profile among HIV-1 infections experiencing ART with low-level viral load in Guangdong China during 2011–2022: A retrospective study

Y Lan, X Ling, X Deng, Y Lin, J Li, L Li… - Infection and Drug …, 2023 - Taylor & Francis
Background Antiretroviral therapy (ART) efficiently reduces the morbidities and mortalities
caused by HIV-1 infection and prevents the HIV epidemic. However, virologic failure (VF) …

Changes to inflammatory markers during 5 years of viral suppression and during viral blips in people with HIV initiating different integrase inhibitor based regimens

NT Funderburg, SSY Huang, C Cohen… - Frontiers in …, 2024 - frontiersin.org
Background Heightened levels of inflammatory markers are linked to increased
morbidity/mortality in people with HIV (PWH) and often remain elevated after virologic …

Relevance of biomarkers indicating gut damage and microbial translocation in people living with HIV

J Ouyang, J Yan, X Zhou, S Isnard… - Frontiers in …, 2023 - frontiersin.org
The intestinal barrier has the daunting task of allowing nutrient absorption while limiting the
entry of microbial products into the systemic circulation. HIV infection disrupts the intestinal …

CD8 lymphocytes mitigate HIV-1 persistence in lymph node follicular helper T cells during hyperacute-treated infection

OO Baiyegunhi, J Mann, T Khaba, T Nkosi… - Nature …, 2022 - nature.com
HIV persistence in tissue sites despite ART is a major barrier to HIV cure. Detailed studies of
HIV-infected cells and immune responses in native lymph node tissue environment is critical …

Symptomatic and asymptomatic neurocognitive impairment, ART adherence and HIV control: a 4-year observational study

M Trunfio, E Vuaran, D Vai, C Quarta, A Di Stefano… - AIDS and Behavior, 2024 - Springer
We assessed whether symptomatic neurocognitive impairment (NCI) and asymptomatic NCI-
of which the clinical relevance is debated-affect HIV control and the role of ART adherence …

Retrospective longitudinal analysis of low-level viremia among HIV-1 infected adults on antiretroviral therapy in Kenya

A Aoko, S Pals, T Ngugi, E Katiku, R Joseph… - …, 2023 - thelancet.com
Background HIV low-level viremia (LLV)(51–999 copies/mL) can progress to treatment
failure and increase potential for drug resistance. We analyzed retrospective longitudinal …

Curcumin enhances elvitegravir concentration and alleviates oxidative stress and inflammatory response

S Godse, L Zhou, N Sinha, S Kodidela, A Kumar… - Scientific reports, 2023 - nature.com
In this study, we investigated the potential of using curcumin (CUR) as an adjuvant to
enhance the delivery of antiretroviral drug elvitegravir (EVG) across the BBB, and alleviate …

Factors Associated with Low-Level Viremia in People Living with HIV in the Italian Antiviral Response Cohort Analysis Cohort: A Case–Control Study

F Lombardi, E Bruzzesi, YR Bouba… - AIDS Research and …, 2024 - liebertpub.com
Despite effective antiretroviral therapies (ARTs), a subset of people living with HIV (PLWH)
still experience low-level viremia (LLV, ie, 50–1,000 copies/mL). The present study …

Factors associated with low-level viraemia in people with HIV starting antiretroviral therapy: a Swedish observational study

H Brattgård, P Björkman, P Nowak, CJ Treutiger… - PLoS …, 2022 - journals.plos.org
Objective Low-level viraemia (LLV) occurs in some people with HIV (PWH) receiving
antiretroviral therapy (ART) and has been linked to inferior treatment outcomes. We …