Protein post-translational modification (PTM) is a covalent process that occurs in proteins
during or after translation through the addition or removal of one or more functional groups …

Mass spectrometry (MS) has become a central technique in cancer research. The ability to
analyze various types of biomolecules in complex biological matrices makes it well suited for …

Glycans are major constituents of extracellular vesicles (EVs). Alterations in the
glycosylation pathway are a common feature of cancer cells, which gives rise to de novo or …

O-glycosylation is a highly frequent post-translation modification of proteins, with important
functional implications in both physiological and disease contexts. The biosynthesis of O …

The transformation from normal to malignant phenotype in human cancers is associated with
aberrant cell-surface glycosylation. It has frequently been reported that MUC1, the heavily …

Extracellular vesicles (EVs) are a heterogeneous group of small secreted particles involved
in intercellular communication and mediating a broad spectrum of biological functions. EVs …

Gastric cancer is a dominating cause of cancer-associated mortality with limited therapeutic
options. Here, we show that syndecan-4 (SDC4), a transmembrane proteoglycan, is highly …

Gastric cancer (GC) is the fourth leading cause of cancer-related deaths worldwide and,
therefore, it is urgent to develop new and more efficient therapeutic approaches. Foretinib …

Simple Summary Alterations in glycosylation are frequently observed in cancer cells.
Different strategies have been proposed to increase drug delivery to the tumor site in order …

The clinical performance of the therapeutic monoclonal antibody trastuzumab in the
treatment of ErbB2-positive unresectable gastric cancer (GC) is severely hampered by the …