Conventional immunohistochemistry (IHC) is a widely used diagnostic technique in tissue
pathology. However, this technique is associated with a number of limitations, including high …

The expression of Ki67 is strongly associated with tumor cell proliferation and growth, and is
widely used in routine pathological investigation as a proliferation marker. The nuclear …

Ki67 has potential clinical importance in breast cancer but has yet to see broad acceptance
due to inter-laboratory variability. Here we tested an open source and calibrated automated …

Ki67 expression has been a valuable prognostic variable in breast cancer, but has not seen
broad adoption due to lack of standardization between institutions. Automation could …

Simple Summary Cellular proliferation is a central determinant of breast cancer recurrence
risk and response to chemotherapy. The discovery of the Ki-67 antibody by Dr. Johannes …

Being a non-histone protein, Ki-67 is one of the essential biomarkers for the
immunohistochemical assessment of proliferation rate in breast cancer screening and …

The presence of tumor-infiltrating lymphocytes (TIL), reflecting host immune activity, is
frequently correlated with better clinical outcomes, particularly in HER2-positive and triple …

Abstract Purpose The Ki67 proliferation index is a prognostic and predictive marker in breast
cancer. Manual scoring is prone to inter-and intra-observer variability. The aims of this study …

Ki67 represents an immunohistochemical nuclear localized marker that is widely used in
surgical pathology. Nuclear immunoreactivity for Ki67 indicates that cells are cycling and are …

Background Ki67 labeling index (LI) is critical for treatment options and prognosis evaluation
in breast cancer. Visual assessment (VA) is widely used to assess Ki67 LI, but has some …