PP2A is a highly conserved eukaryotic serine/threonine protein phosphatase of the PPP
family of phosphatases with fundamental cellular functions. In cells, PP2A targets specific …

Oxidative stress is known as a major contributing factor involved in oocyte aging, which
negatively affects oocyte quality and development after fertilization. Melatonin is an effective …

Meiosis is required to reduce to haploid the diploid genome content of a cell, generating
gametes—oocytes and sperm—with the correct number of chromosomes. To achieve this …

Protein phosphorylation is a reversible post-translation modification essential in cell
signaling. This study addresses a long-standing question as to how the most abundant …

Postovulatory aging of the mammalian oocytes causes deterioration of oocytes through
several factors including oxidative stress. Keeping that in mind, we aimed to investigate the …

Excessive long-term fluoride intake is associated with several health problems, including
infertility. However, limited information is available on the toxic effects of fluoride exposure …

Abstract The PPP2R2A gene encodes the B55α regulatory subunit of PP2A. Here, we report
that PPP2R2A is hemizygously lost in~ 42% of prostate adenocarcinomas, correlating with …

Introduction Monoclonal antibodies and targeted therapies against HER2+ breast cancer
has improved overall and disease-free survival in patients; however, encountering drug …

The serine/threonine protein phosphatase 2A (PP2A) is a master regulator of the complex
cellular signaling that occurs during all stages of mammalian development. PP2A is …

Background Sheep and goats have undergone domestication and improvement to produce
similar phenotypes, which have been greatly impacted by structural variants (SVs). Here, we …