There is a dire need to discover new targets for Alzheimer's disease (AD) drug development.
Decreased neuronal glucose metabolism that occurs in AD brain could play a central role in …

A facilitative transport system exists on the blood–brain barrier (BBB) that has been tacitly
assumed to be a path for glutamate entry to the brain. However, glutamate is a non-essential …

Cancer cells can use a variety of metabolic substrates to fulfill the bioenergetic and
biosynthetic needs of their oncogenic program. Besides bioenergetics, cancer cell …

Hotspot mutations in the isocitrate dehydrogenase 1 (IDH1) gene occur in a number of
human cancers and confer a neomorphic enzyme activity that catalyzes the conversion of α …

Regulation of glutamate metabolism via glutamate dehydrogenase (GDH) might be the
promising therapeutic approach for treating neurodegenerative disorders. In the central …

Glutamate dehydrogenase (GDH) of animal cells is usually considered to be a mitochondrial
enzyme. However, this enzyme has recently been reported to be also present in nucleus …

Deregulation of glutamate homeostasis is associated with degenerative neurological
disorders. Glutamate dehydrogenase (GDH) is important for glutamate metabolism and …

Cancer cells rapidly consume glutamine as a carbon and nitrogen source to support
proliferation, but the cell number continues to increase exponentially after glutamine is …

A growing body of evidence supports the idea that mitochondrial dysfunction might
represent a key feature of Parkinson's disease (PD). Central regulators of energy production …

Glutamate is the main excitatory neurotransmitter in the brain, and its excitatory neurotoxicity
is closely related to the occurrence and development of Alzheimer's disease. However …