Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human malignancies
with a 5-year survival rate of 8%. Dense, fibrotic stroma associated with pancreatic tumors is …

Pancreatic stellate cells (PSCs) are the major contributor to the aggressive, metastatic, and
resilient nature of pancreatic ductal adenocarcinoma (PDAC), which has a poor prognosis …

Pancreatic ductal adenocarcinoma is characterised by a dense desmoplastic stroma
composed of stromal cells and extracellular matrix (ECM). This barrier severely impairs drug …

BACKGROUND & AIMS: Patients with pancreatic ductal adenocarcinoma are deficient in
vitamin A, resulting in activation of pancreatic stellate cells (PSCs). We investigated whether …

Until now, no specific therapies are available to inhibit pancreatic fibrosis, a constant
pathological feature of chronic pancreatitis and pancreatic cancer. One major reason is the …

Background Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant disease with a
very poor prognosis. To date patient outcomes have not improved principally due to the …

Tissue fibrosis is one of the characteristics of chronic pancreatitis and pancreatic
adenocarcinoma. Activated pancreatic stellate cells (PSC) play a central role in this process …

Background and aims: Activated pancreatic stellate cells (PSCs) are implicated in the
production of alcohol induced pancreatic fibrosis. PSC activation is invariably associated …

Purpose: Despite significant progress in understanding the molecular pathology of
pancreatic cancer and its precursor lesion: pancreatic intraepithelial neoplasia (PanIN) …

Pancreatic stellate cells (PSCs) play a crucial role in pancreatic fibrogenesis in chronic
pancreatitis and in the desmoplastic reaction of pancreatic cancer. When PSCs are …