Transcription of DNA is a fundamental process in all cellular organisms. The enzyme
responsible for transcription, RNA polymerase, is conserved in general architecture and …

The current tuberculosis (TB) predicament poses numerous challenges and therefore every
incremental scientific work and all positive socio-political engagements, are steps taken in …

Drug-resistant bacterial pathogens pose an urgent public-health crisis. Here, we report the
discovery, from microbial-extract screening, of a nucleoside-analog inhibitor that inhibits …

Objective To investigate the mutations within the whole rpoB gene of Mycobacterium
tuberculosis and analyze their effects on rifampin (RIF) resistance based on crystal structure …

Low-level rifampin resistance associated with specific rpoB mutations (referred as
“disputed”) in Mycobacterium tuberculosis is easily missed by some phenotypic methods. To …

Tuberculosis (TB) is a long-term infection caused by the bacteria Mycobacterium
tuberculosis, which continues to kill more people each year than any other infectious illness …

Covering: 2016 to 2022 RNA polymerase (RNAP) is the central enzyme in bacterial gene
expression representing an attractive and validated target for antibiotics. Two well-known …

Fidaxomicin is an antibacterial drug in clinical use for treatment of Clostridium difficile
diarrhea. The active ingredient of fidaxomicin, lipiarmycin A3 (Lpm), functions by inhibiting …

Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), remains a
leading cause of death due to infection in humans. To more effectively combat this …

The ever-increasing incidence of drug-resistant Mycobacterium tuberculosis infections has
invigorated the focus on the discovery and development of novel treatment options. The …