Molecular aspects of fructose metabolism and metabolic disease

MA Herman, MJ Birnbaum - Cell metabolism, 2021 - cell.com
Excessive sugar consumption is increasingly considered as a contributor to the emerging
epidemics of obesity and the associated cardiometabolic disease. Sugar is added to the diet …

Noninvasive biomarkers in NAFLD and NASH—current progress and future promise

VWS Wong, LA Adams, V de Lédinghen… - Nature reviews …, 2018 - nature.com
Nonalcoholic fatty liver disease (NAFLD) affects 25% of the global adult population and is
the most common chronic liver disease worldwide. Nonalcoholic steatohepatitis (NASH) is …

Quantification of liver fat content with ultrasound: a WFUMB position paper

G Ferraioli, A Berzigotti, RG Barr, BI Choi… - Ultrasound in medicine …, 2021 - Elsevier
New ultrasound methods that can be used to quantitatively assess liver fat content have
recently been developed. These quantitative ultrasound (QUS) methods are based on the …

Clinical and molecular biomarkers for diagnosis and staging of NAFLD

S Di Mauro, A Scamporrino, A Filippello… - International journal of …, 2021 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is the most common hepatic pathology in
industrialized countries, affecting about 25% of the general population. NAFLD is a benign …

Open-label phase II study evaluating safety and efficacy of the non-steroidal farnesoid X receptor agonist PX-104 in non-alcoholic fatty liver disease

S Traussnigg, E Halilbasic, H Hofer, P Munda… - Wiener klinische …, 2021 - Springer
Background The PX-104 is an oral non-steroidal agonist for the farnesoid X receptor (FXR),
a key regulator of bile acid (BA), glucose and lipid homeostasis. Aims and methods This …

Genetic and hormonal control of hepatic steatosis in female and male mice1

F Norheim, ST Hui, E Kulahcioglu, M Mehrabian… - Journal of lipid …, 2017 - ASBMB
The etiology of nonalcoholic fatty liver disease is complex and influenced by factors such as
obesity, insulin resistance, hyperlipidemia, and sex. We now report a study on sex difference …

Imaging of nonalcoholic fatty liver disease and its clinical utility

E Chartampilas - Hormones, 2018 - Springer
The prevalence of nonalcoholic fatty liver disease has been continuously rising over the last
three decades and is projected to become the most common indication for liver …

Noninvasive differentiation between hepatic steatosis and steatohepatitis with MR imaging enhanced with USPIOs in patients with nonalcoholic fatty liver disease: a …

LP Smits, BF Coolen, MD Panno, JH Runge, WH Nijhof… - Radiology, 2016 - pubs.rsna.org
Purpose To (a) study the optimal timing and dosing for ultrasmall superparamagnetic iron
oxide particle (USPIO)–enhanced magnetic resonance (MR) imaging of the liver in …

Nonalcoholic fatty liver disease: Noninvasive methods of diagnosing hepatic steatosis

R AlShaalan, M Aljiffry, S Al-Busafi… - Saudi Journal of …, 2015 - journals.lww.com
Hepatic steatosis is the buildup of lipids within hepatocytes. It is the simplest stage in
nonalcoholic fatty liver disease (NAFLD). It occurs in approximately 30% of the general …

Accuracy of imaging methods for steatohepatitis diagnosis in non‐alcoholic fatty liver disease patients: A systematic review

G Besutti, L Valenti, G Ligabue, MC Bassi… - Liver …, 2019 - Wiley Online Library
Abstract Background & Aims Non‐invasive tests to diagnose non‐alcoholic steatohepatitis
(NASH) are urgently needed. This systematic review aims to evaluate imaging accuracy in …