AP-1 (activating protein-1) is a collective term referring to dimeric transcription factors
composed of Jun, Fos or ATF (activating transcription factor) subunits that bind to a common …

▪ Abstract In eukaryotic cells, most proteins in the cytosol and nucleus are degraded via the
ubiquitin-proteasome pathway. The 26S proteasome is a 2.5-MDa molecular machine built …

Hypoxia induces a group of physiologically important genes such as erythropoietin and
vascular endothelial growth factor. These genes are transcriptionally up-regulated by …

In 1986, we proposed that polypeptide sequences enriched in proline (P), glutamic acid (E),
serine (S) and threonine (T) target proteins for rapid destruction. For much of the past …

This article reviews findings up to the end of 1997 about the inducible transcription factors
(ITFs) c-Jun, JunB, JunD, c-Fos, FosB, Fra-1, Fra-2, Krox-20 (Egr-2) and Krox-24 (NGFI-A …

The half-life of the green fluorescent protein (GFP) was determined biochemically in cultured
mouse LA-9 cells. The wild-type protein was found to be stable with a half-life of~ 26 h, but …

The c-Myc oncoprotein is a transcription factor which is a critical regulator of cellular
proliferation. Deregulated expression of c-Myc is associated with many human cancers …

The human proto‐oncogene c‐myc encodes a highly unstable transcription factor that
promotes cell proliferation. Although the extreme instability of Myc plays an important role in …

Ligand-dependent down-regulation of the glucocorticoid receptor (GR) has been shown to
limit hormone responsiveness, but the mechanisms involved in this process are poorly …

The 26S proteasome complex engages in an ATP-dependent proteolytic degradation of a
variety of oncoproteins, transcription factors, cell cycle specific cyclins, cyclin-dependent …