The promise of microRNA-based therapies in Alzheimer's disease: challenges and perspectives

H Walgrave, L Zhou, B De Strooper, E Salta - Molecular …, 2021 - Springer
Multi-pathway approaches for the treatment of complex polygenic disorders are emerging as
alternatives to classical monotarget therapies and microRNAs are of particular interest in …

Cellular commitment in the developing cerebellum

H Marzban, MR Del Bigio, J Alizadeh… - Frontiers in cellular …, 2015 - frontiersin.org
The mammalian cerebellum is located in the posterior cranial fossa and is critical for motor
coordination and non-motor functions including cognitive and emotional processes. The …

Circulating brain-enriched microRNAs as novel biomarkers for detection and differentiation of neurodegenerative diseases

KS Sheinerman, JB Toledo, VG Tsivinsky… - Alzheimer's research & …, 2017 - Springer
Background Minimally invasive specific biomarkers of neurodegenerative diseases (NDs)
would facilitate patient selection and disease progression monitoring. We describe the …

De-repression of FOXO3a death axis by microRNA-132 and-212 causes neuronal apoptosis in Alzheimer's disease

HKA Wong, T Veremeyko, N Patel… - Human molecular …, 2013 - academic.oup.com
Alzheimer's disease (AD) is a multifactorial and fatal neurodegenerative disorder for which
the mechanisms leading to profound neuronal loss are incompletely recognized. MicroRNAs …

General principals of miRNA biogenesis and regulation in the brain

D O'carroll, A Schaefer - Neuropsychopharmacology, 2013 - nature.com
MicroRNAs (miRNAs) are small, noncoding RNAs that mediate posttranscriptional gene
suppression in a sequence-specific manner. The ability of a single miRNA species to target …

Differential innate immune response programs in neuronal subtypes determine susceptibility to infection in the brain by positive-stranded RNA viruses

H Cho, SC Proll, KJ Szretter, MG Katze, M Gale Jr… - Nature medicine, 2013 - nature.com
Although susceptibility of neurons in the brain to microbial infection is a major determinant of
clinical outcome, little is known about the molecular factors governing this vulnerability. Here …

MicroRNA networks direct neuronal development and plasticity

NFM Olde Loohuis, A Kos, GJM Martens… - Cellular and Molecular …, 2012 - Springer
MicroRNAs (miRNAs) constitute a class of small, non-coding RNAs that act as post-
transcriptional regulators of gene expression. In neurons, the functions of individual miRNAs …

MicroRNAs as effectors of brain function with roles in ischemia and injury, neuroprotection, and neurodegeneration

JA Saugstad - Journal of Cerebral Blood Flow & Metabolism, 2010 - journals.sagepub.com
MicroRNAs are small RNAs that function as regulators of posttranscriptional gene
expression. MicroRNAs are encoded by genes, and processed to form ribonucleoprotein …

[HTML][HTML] microRNA-132 regulates gene expression programs involved in microglial homeostasis

H Walgrave, A Penning, G Tosoni, S Snoeck, K Davie… - Iscience, 2023 - cell.com
Summary microRNA-132 (miR-132), a known neuronal regulator, is one of the most robustly
downregulated microRNAs (miRNAs) in the brain of Alzheimer's disease (AD) patients …

Hippocampal subregion-specific microRNA expression during epileptogenesis in experimental temporal lobe epilepsy

JA Gorter, A Iyer, I White, A Colzi, EA van Vliet… - Neurobiology of …, 2014 - Elsevier
Since aberrant miRNA expression has been implicated in numerous brain diseases, we
studied miRNA expression and miRNA regulation of important signaling pathways during …