The shared role of cholesterol in neuronal and peripheral inflammation
Neurodegeneration and its loss of cognitive function is associated with inflammation and an
accumulation of lipids. In the periphery, cholesterol's uptake drives a major component of …
accumulation of lipids. In the periphery, cholesterol's uptake drives a major component of …
Lipid nanodomains and receptor signaling: From actin-based organization to membrane mechanics
The plasma membrane serves as the primary barrier between the cell's interior and its
external surroundings, which places it at the forefront of intercellular communication …
external surroundings, which places it at the forefront of intercellular communication …
Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol
H Wang, JA Kulas, C Wang… - Proceedings of the …, 2021 - National Acad Sciences
Alzheimer's disease (AD) is characterized by the presence of amyloid β (Aβ) plaques, tau
tangles, inflammation, and loss of cognitive function. Genetic variation in a cholesterol …
tangles, inflammation, and loss of cognitive function. Genetic variation in a cholesterol …
The role of high cholesterol in age-related COVID19 lethality
Coronavirus disease 2019 (COVID19) is a respiratory infection caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) originating in Wuhan, China in 2019 …
respiratory syndrome coronavirus 2 (SARS-CoV-2) originating in Wuhan, China in 2019 …
Studies on the mechanism of general anesthesia
MA Pavel, EN Petersen, H Wang… - Proceedings of the …, 2020 - National Acad Sciences
Inhaled anesthetics are a chemically diverse collection of hydrophobic molecules that
robustly activate TWIK-related K+ channels (TREK-1) and reversibly induce loss of …
robustly activate TWIK-related K+ channels (TREK-1) and reversibly induce loss of …
Hydroxychloroquine blocks SARS-CoV-2 entry into the endocytic pathway in mammalian cell culture
Hydroxychloroquine (HCQ), a drug used to treat lupus and malaria, was proposed as a
treatment for SARS-coronavirus-2 (SARS-CoV-2) infection, albeit with controversy. In vitro …
treatment for SARS-coronavirus-2 (SARS-CoV-2) infection, albeit with controversy. In vitro …
Membrane phospholipids control gating of the mechanosensitive potassium leak channel TREK1
PAM Schmidpeter, JT Petroff, L Khajoueinejad… - Nature …, 2023 - nature.com
Tandem pore domain (K2P) potassium channels modulate resting membrane potentials and
shape cellular excitability. For the mechanosensitive subfamily of K2Ps, the composition of …
shape cellular excitability. For the mechanosensitive subfamily of K2Ps, the composition of …
Cholesterol regulation of membrane proteins revealed by two-color super-resolution imaging
Cholesterol and phosphatidyl inositol 4, 5-bisphosphate (PIP2) are hydrophobic molecules
that regulate protein function in the plasma membrane of all cells. In this review, we discuss …
that regulate protein function in the plasma membrane of all cells. In this review, we discuss …
Roles of membrane domains in integrin-mediated cell adhesion
The composition and organization of the plasma membrane play important functional and
regulatory roles in integrin signaling, which direct many physiological and pathological …
regulatory roles in integrin signaling, which direct many physiological and pathological …
Phospholipid membranes as chemically and functionally tunable materials
The sheet‐like lipid bilayer is the fundamental structural component of all cell membranes.
Its building blocks are phospholipids and cholesterol. Their amphiphilic structure …
Its building blocks are phospholipids and cholesterol. Their amphiphilic structure …