Targeting extracellular signal-regulated protein kinase 1/2 (ERK1/2) in cancer: an update on pharmacological small-molecule inhibitors
L Fu, S Chen, G He, Y Chen, B Liu - Journal of medicinal chemistry, 2022 - ACS Publications
Extracellular signal-regulated protein kinase 1/2 (ERK1/2), the only known substrate of
MEK1/2, is located downstream of the RAS-RAF-MEK-ERK (MAPK) pathway and is …
MEK1/2, is located downstream of the RAS-RAF-MEK-ERK (MAPK) pathway and is …
A guide to ERK dynamics, part 1: mechanisms and models
A Ram, D Murphy, N DeCuzzi, M Patankar… - Biochemical …, 2023 - portlandpress.com
Extracellular signal-regulated kinase (ERK) has long been studied as a key driver of both
essential cellular processes and disease. A persistent question has been how this single …
essential cellular processes and disease. A persistent question has been how this single …
Kinetics of RTK activation determine ERK reactivation and resistance to dual BRAF/MEK inhibition in melanoma
The combination of BRAF and MEK inhibitors (BRAFi/MEKi) has shown promising response
rates in treating BRAF-mutant melanoma by inhibiting ERK activation. However, treatment …
rates in treating BRAF-mutant melanoma by inhibiting ERK activation. However, treatment …
Spatiotemporal control of ERK pulse frequency coordinates fate decisions during mammary acinar morphogenesis
The signaling events controlling proliferation, survival, and apoptosis during mammary
epithelial acinar morphogenesis remain poorly characterized. By imaging single-cell ERK …
epithelial acinar morphogenesis remain poorly characterized. By imaging single-cell ERK …
Deep model predictive control of gene expression in thousands of single cells
JB Lugagne, CM Blassick, MJ Dunlop - Nature Communications, 2024 - nature.com
Gene expression is inherently dynamic, due to complex regulation and stochastic
biochemical events. However, the effects of these dynamics on cell phenotypes can be …
biochemical events. However, the effects of these dynamics on cell phenotypes can be …
Automatic detection of spatio-temporal signaling patterns in cell collectives
Increasing experimental evidence points to the physiological importance of space–time
correlations in signaling of cell collectives. From wound healing to epithelial homeostasis to …
correlations in signaling of cell collectives. From wound healing to epithelial homeostasis to …
An improved Erk biosensor detects oscillatory Erk dynamics driven by mitotic erasure during early development
SG Wilcockson, L Guglielmi, PA Rodriguez, M Amoyel… - Developmental cell, 2023 - cell.com
Extracellular signal-regulated kinase (Erk) signaling dynamics elicit distinct cellular
responses in a variety of contexts. The early zebrafish embryo is an ideal model to explore …
responses in a variety of contexts. The early zebrafish embryo is an ideal model to explore …
Rapid optogenetic clustering in the cytoplasm with BcLOVclust
Protein clustering is a powerful form of optogenetic control, yet remarkably few proteins are
known to oligomerize with light. Recently, the photoreceptor BcLOV4 was found to form …
known to oligomerize with light. Recently, the photoreceptor BcLOV4 was found to form …
Dynamical information synergy in biochemical signaling networks
Biological cells encode information about their environment through biochemical signaling
networks that control their internal state and response. This information is often encoded in …
networks that control their internal state and response. This information is often encoded in …
LITOS: a versatile LED illumination tool for optogenetic stimulation
TC Höhener, AE Landolt, C Dessauges, L Hinderling… - Scientific reports, 2022 - nature.com
Optogenetics has become a key tool to manipulate biological processes with high spatio-
temporal resolution. Recently, a number of commercial and open-source multi-well …
temporal resolution. Recently, a number of commercial and open-source multi-well …