The dawn of a new era: targeting the “undruggables” with antibody-based therapeutics
The high selectivity and affinity of antibodies toward their antigens have made them a highly
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …
Gold nanomaterials at work in biomedicine
Gold is a precious metal with a characteristic bright and beautiful hue known as the golden
yellow color.(1) As of 2012, a total of 174,100 tons of Au has been mined in human history …
yellow color.(1) As of 2012, a total of 174,100 tons of Au has been mined in human history …
Biomineralized metal–organic framework nanoparticles enable intracellular delivery and endo-lysosomal release of native active proteins
TT Chen, JT Yi, YY Zhao, X Chu - Journal of the American …, 2018 - ACS Publications
Efficient delivery and endo-lysosomal release of active proteins in living cells remain a
challenge in protein-based theranostics. We report a novel protein delivery platform using …
challenge in protein-based theranostics. We report a novel protein delivery platform using …
In vitro and in vivo characterization of pharmaceutical nanocarriers used for drug delivery
AK Jain, S Thareja - Artificial cells, nanomedicine, and …, 2019 - Taylor & Francis
Nanotechnology has emerged strongly in most of the field of sciences at a tiny scale. At this
size, atoms and molecules work differently and present a diversity of amazing and appealing …
size, atoms and molecules work differently and present a diversity of amazing and appealing …
Delivery of drugs, proteins, and nucleic acids using inorganic nanoparticles
Inorganic nanoparticles provide multipurpose platforms for a broad range of delivery
applications. Intrinsic nanoscopic properties provide access to unique magnetic and optical …
applications. Intrinsic nanoscopic properties provide access to unique magnetic and optical …
Self-assembly of extracellular vesicle-like metal–organic framework nanoparticles for protection and intracellular delivery of biofunctional proteins
The intracellular delivery of biofunctional enzymes or therapeutic proteins through systemic
administration is of great importance in therapeutic intervention of various diseases …
administration is of great importance in therapeutic intervention of various diseases …
Polymers for cytosolic protein delivery
J Lv, Q Fan, H Wang, Y Cheng - Biomaterials, 2019 - Elsevier
Cytosolic protein delivery offers opportunities to develop protein-based therapeutics
specifically modulate intracellular processes, especially those linked to 'undruggable'targets …
specifically modulate intracellular processes, especially those linked to 'undruggable'targets …
DNA-functionalized metal–organic framework nanoparticles for intracellular delivery of proteins
Due to their large size, charged surfaces, and environmental sensitivity, proteins do not
naturally cross cell-membranes in intact form and, therefore, are difficult to deliver for both …
naturally cross cell-membranes in intact form and, therefore, are difficult to deliver for both …
Biomolecular coronas provide the biological identity of nanosized materials
Fundamentally, all interactions between the nanoparticle corona complex and the biological
machinery are mediated by physical forces common to all molecular systems. The …
machinery are mediated by physical forces common to all molecular systems. The …
Rational design of nanocarriers for intracellular protein delivery
Protein/antibody therapeutics have exhibited the advantages of high specificity and activity
even at an extremely low concentration compared to small molecule drugs. However, they …
even at an extremely low concentration compared to small molecule drugs. However, they …