Osteoarthritis (OA) is the most common cause of disability worldwide among the elderly.
Alarmingly, the incidence of OA in individuals less than 40 years of age is rising, likely due to …

Osteoarthritis (OA) is a progressive disease and OA pain intensity is related to ongoing
pathophysiological changes. However, OA pain is complex and multimodal; its …

Extracellular RNAs (exRNAs) are secreted by nearly all cell types and are now known to
play multiple physiological roles. In humans, exRNA populations are found in nearly any …

The aim of this study was to review aspects of the pathobiology of the meniscus in health
and disease and show how degeneration of the meniscus can contribute to deleterious …

Aims Metabolic profiling is a top-down method of analysis looking at metabolites, which are
the intermediate or end products of various cellular pathways. Our primary objective was to …

Abstract» While the gross mechanical abnormalities contributing to posttraumatic
osteoarthritis (PTOA) have been well described, new research is demonstrating that these …

Chronic inflammation, synovial hyperplasia, and local hypoxia lead to synovial cell
activation causing severe joint damage in chronic-inflammatory rheumatoid arthritis (RA) …

Background: The intra-articular immune response after ligamentous, meniscal, or focal
chondral knee injuries likely plays a role in intra-articular healing and the onset and …

The past two decades have built on the successes of the Human Genome Project identifying
the impact of genetics and genomics on human traits. Given the importance of exercise in …

Prolidase expression in knee osteoarthritis and healthy cont... : Medicine Prolidase expression
in knee osteoarthritis and healthy controls: Observational study : Medicine Log in or Register …