Orally administered drug entities have to survive the harsh gastrointestinal environment,
penetrate the enteric epithelia and circumvent hepatic metabolism before reaching the …

The delivery of drugs and bioactive compounds via the lymphatic system is complex and
dependent on the physiological uniqueness of the system. The lymphatic route plays an …

Abstract Pueraria lobata (Willd.) Ohwi is a medicinal and edible homologous plant with a
long history in China. Puerarin, the main component isolated from the root of Pueraria …

Introduction: Thirty percent of top marketed drugs in the USA and 70% of all new drug
candidates are lipophilic and exhibit poor water solubility. With such physicochemical …

Traditional Chinese medicine (TCM) has been practiced for thousands of years with a recent
increase in popularity. Despite promising biological activities of active ingredients and …

Introduction: Brain is supposed to be the most complicated part of the body which is very far
from the reach of drug moieties. The drug entry in to the brain region depends upon various …

This work aims to investigate the impact of different amount of oil or surfactant included in
self-microemulsifying drug delivery systems on the intestinal lymphatic transport of sirolimus …

Retinal pericyte loss is one of the histopathological hallmarks of early diabetic retinopathy.
Puerarin (4′-7-dihydroxy-8-beta-d-glucosylisoflavone), which is an isoflavone-C-glucoside …

Felodipine is a calcium channel blocker, which shows low oral bioavailability (< 15%) owing
to poor water solubility and high first pass metabolism. The aim of the present investigation …

The present study aims to develop self-microemulsifying drug delivery systems (SMEDDS)
in sustained-release pellets of puerarin to enhance the oral bioavailability of puerarin. The …