Polymorphonuclear neutrophils, besides their involvement in primary defense against
infections–mainly through phagocytosis, generation of toxic molecules, release of enzymes …

Leishmaniasis is a parasitic, widespread, and neglected disease that affects more than 90
countries in the world. More than 20 Leishmania species cause different forms of …

Leishmania is a genus of protozoan parasites that are transmitted by the bite of
phlebotomine sandflies and give rise to a range of diseases (collectively known as …

Infection with the obligate intracellular protozoan Leishmania is thought to be initiated by
direct parasitization of macrophages, but the early events following transmission to the skin …

Diseases caused by Leishmania present a worldwide problem, and current therapeutic
approaches are unable to achieve a sterile cure. Leishmania is able to persist in host cells …

Previously, neutrophils were largely ignored in the pattern recognition receptor (PRR)
signaling field. However, interest in neutrophil biology has been revitalized by emerging …

Neutrophils are rapidly and massively recruited to sites of microbial infection, where they
can influence the recruitment of dendritic cells. Here, we have analyzed the role of …

Neutrophils are the first cells recruited to the dermal site of Leishmania infection following
injection by needle or sand fly bite. The role of neutrophils in either promoting or …

Neutrophils play an active role in the control of infections caused by intracellular pathogens
such as Leishmania. In the present study, we investigated the effect of neutrophil depletion …

Leishmaniases are vector-borne diseases of serious public health importance. During a
sand fly blood meal, Leishmania parasites are deposited in the host dermis where …