Machine learning for brain age prediction: Introduction to methods and clinical applications

L Baecker, R Garcia-Dias, S Vieira, C Scarpazza… - …, 2021 - thelancet.com
The rise of machine learning has unlocked new ways of analysing structural neuroimaging
data, including brain age prediction. In this state-of-the-art review, we provide an …

Predicting age using neuroimaging: innovative brain ageing biomarkers

JH Cole, K Franke - Trends in neurosciences, 2017 - cell.com
The brain changes as we age and these changes are associated with functional
deterioration and neurodegenerative disease. It is vital that we better understand individual …

Deep learning encodes robust discriminative neuroimaging representations to outperform standard machine learning

A Abrol, Z Fu, M Salman, R Silva, Y Du, S Plis… - Nature …, 2021 - nature.com
Recent critical commentaries unfavorably compare deep learning (DL) with standard
machine learning (SML) approaches for brain imaging data analysis. However, their …

[HTML][HTML] Multimodality neuroimaging brain-age in UK biobank: relationship to biomedical, lifestyle, and cognitive factors

JH Cole - Neurobiology of aging, 2020 - Elsevier
The brain-age paradigm is proving increasingly useful for exploring aging-related disease
and can predict important future health outcomes. Most brain-age research uses structural …

Brain age and other bodily 'ages': implications for neuropsychiatry

JH Cole, RE Marioni, SE Harris, IJ Deary - Molecular psychiatry, 2019 - nature.com
As our brains age, we tend to experience cognitive decline and are at greater risk of
neurodegenerative disease and dementia. Symptoms of chronic neuropsychiatric diseases …

The relationship between obesity and cognitive health and decline

L Dye, NB Boyle, C Champ, C Lawton - Proceedings of the nutrition …, 2017 - cambridge.org
The relationship between obesity and cognitive impairment is important given the globally
ageing population in whom cognitive decline and neurodegenerative disorders will carry …

Brain-age in midlife is associated with accelerated biological aging and cognitive decline in a longitudinal birth cohort

ML Elliott, DW Belsky, AR Knodt, D Ireland… - Molecular …, 2021 - nature.com
An individual's brainAGE is the difference between chronological age and age predicted
from machine-learning models of brain-imaging data. BrainAGE has been proposed as a …

Obesity and ageing: Two sides of the same coin

BT Tam, JA Morais, S Santosa - Obesity Reviews, 2020 - Wiley Online Library
Conditions and comorbidities of obesity mirror those of ageing and age‐related diseases.
Obesity and ageing share a similar spectrum of phenotypes such as compromised genomic …

[HTML][HTML] Dispersion of functional gradients across the adult lifespan

RAI Bethlehem, C Paquola, J Seidlitz, L Ronan… - Neuroimage, 2020 - Elsevier
Ageing is commonly associated with changes to segregation and integration of functional
brain networks, but, in isolation, current network-based approaches struggle to elucidate …

Association between midlife obesity and its metabolic consequences, cerebrovascular disease, and cognitive decline

F Morys, M Dadar, A Dagher - The Journal of Clinical …, 2021 - academic.oup.com
Context Chronic obesity is associated with several complications, including cognitive
impairment and dementia. However, we have only piecemeal knowledge of the mechanisms …